A loss-of-function mutation in the ion channel responsible for the generation of end-plate potentials results in a diminished permeability of the ion channel.  1)  How would you experimentally test the effect of the mutation on the functional properties of the cell (synapse)? You should discuss the types of postsynaptic responses and physiological parameters you could measure.

Q: A neuron with a resting membrane potential of -75 mV receives multiple inputs giving rise to the…

A: The action potential is a condition of a nerve impulse or electrical activity when there is a…

Q: A graded potential that achieves threshold leads to the generation of an action potential. Which one…

A: Graded potentials are made by outside stimuli in sensory neurons or by neurotransmitters discharged…

Q: During an action potential, what do the transient changes in membrane e permeability allow?

A: The sudden, transitory, propagating, and fast change in the resting membrane potential is called an…

Q: The resting membrane potential of a neuron typically is  70 mV. What does this mean?

A: The nervous system is involved in the coordination and controlling of various activities in the…

Q: You are recording the electrical activity of a cell body with a resting membrane potential of -70…

A: Given; Resting membrane potential of the cell= -70mV No. of stimuli detected by the cell= 3 from…

Q: For a nerve fibre axoplasmic and extracellular ion concentrations were found to be respectively:…

A: An equilibrium environment should be maintained both inside and outside the cell to function…

Q: Which of the following is one major difference? [Choose ] Only action potentials cause…

A: There is difference in the concentration of ions inside and outside the each cell of body and this…

Q: 3. Electrical Signal: The Action Potential In the figure to the left, name the 4 phases of the…

A: Action potential refers to a fast, propagating change in the resting membrane potential of a cell.…

Q: Why are voltage-gated channels important?

A: Facilitated diffusion is a passive transport of ions, which means this process does not need energy…

Q: - In terms of Na and K ion gradient /movement - what causes the action potential (positive charge…

A: The Na+ K+ ion gradient refers to the concentration difference of sodium (Na+) and potassium (K+)…

Q: If the plasma membrane of an electrically excitable cellwere depolarized to threshold in the center…

A: An action potential is defined as a swift increase that is followed by a drop in the voltage or…

Q: atch the description with the statement that best describes the following statements…

A: When a cell is not stimulated, its resting membrane potential is defined as the electrical potential…

Q: of the stages of an action potential, including a description of and explanation for the refractory…

A: The normal resting membrane potential is about -70 mv. The electric signals produced by the neuronal…

Q: In Japan, the consumption of “Fugu” (a kind of sashimi sushi) is considered to be a “manly” act. The…

A: Fugu is a type of pufferfish that is considered a delicacy in Japan. It is typically served as…

Q: mbing fiber depolarizes mbrane potential to en Ca2+ channels. tage-gated channel 2+ Ca²+ Release 2+…

A: The objective of the question is to identify the most direct mechanism causing the postsynaptic…

Q: 3) You are investigating the ionic selectivity of an ion channel opened by activation of a specific…

A: A.                                   E(K+)= RTnFlnOUTIN=8.314×2981×96485ln5140=-0.089≈-89mV…

Q: If neurons fire action potentials when membrane potential reaches -50mV, how would hyperkalemia…

A: Hyperkalemia is a medical condition where there is an excess of potassium ions (K+) in the…

Q: Describe the “all-or-none” principle of action potentials. Does the restoration of a resting…

A: In human physiology, the phenomena of action potential refers to the rapid changes in the membrane…

Q: Ordinarily, a neuron’s trigger zone is activated before any other part ofan axon, so a wave of…

A: Nerve cells are electrically excitable cells that method and transmits information by electrical and…

Q: Each of the following is a correct relationship between action potential phase and channel status…

A: BASIC INFORMATION NEURON   It is the longest cell inside the human body  It is found in the brain…

Q: Grasshopper mouse lives in the desert of Arizona where there are scorpions whose venoms are toxic by…

A: Grasshopper mice are desert-dwelling rodents in the genus Onychomys, which includes three species –…

Q: The ion flows across neuronal membranes at rest and duringan action potential do not significantly…

A: When compared Outside a neuronal cell, the concentration of calcium ions varies greatly when…

Q: 6. 7. Identify the following structures on an image of a synapse: Postsynaptic neuron Presynaptic…

A: Transmission of nerve impulse from one neuron to the next neuron occurs at the synapses. There are…

Q: Select one: O A. hyperpolarizing phase; K channels open B. hyperpolarizing phase: Na channels open…

A: The action potential is the change in the electric potential across the plasma membrane.

Q: Membrane permeability at the falling phase of an action potential is dominated by: O Co-transporters…

A: The neurons send signals over long distances by generating and propagating action potentials over…

Q: Differentiate between ligand - gated and voltage-gated channels.

A: The transportation of molecules across the plasma membrane is carried out with the help of…

Q: The all-or-none principle, associated with the action potential, states that once membrane potential…

A: Neurons are responsible for the electromagnetic conduction of the signals in the form of stimulus.…

Q: Plasma membrane permeability of which of the following ions is most important in generating the…

A: A neuron is negatively charged when it is at rest, more of the negative charge inside the cell than…

Q: With regard to Na+ and K+ equilibrium potentials and the resting and active membrane potentials,…

A: Under all conditions of negative and positive membrane potentials; the concentration of Na+ is…

Q: Epilepsy is a chronic disorder characterized by seizures that result whenneurons in the brain…

A: Introduction: Epilepsy, also referred to as seizures, occurs due to the excessive discharge of the…

Q: Describe leak ion channels and gated ion channels. Howare they responsible for the permeability of a…

A: Ion channels may be classified by gating, i.e. what opens and closes the channels. For example,…

Q: Changes in ion permeability or ion concentration can alter the resting membrane potential of a…

A: A. Increase in [K+]out: H (Hyperpolarization)Higher external potassium concentration will increase…

Q: Refer to the graph showing the course of an action potential. Which of the numbered points along the…

A: As the membrane potential is increased, sodium ion channels open, allowing the entry of sodium ions…

Q: . Suppose a particular neurotransmitter causes an IPSP inpostsynaptic cell X and an EPSP in…

A: Neurons are cells within the nervous system. They transmit information to other nerve cells, muscle,…

Q: Identifying Neurotransmitters 3) Produces response in postsynaptic cell - Qualifying condition:…

A: Postsynaptic potentials are changes in membrane potential that occur due to the action of…

Q: 4. From the list of terms that follow, please label the figure (at least once) below accordingly:…

A: Electrical and biochemical signals are used in conjunction by nerve cells, or neurons, to…

Q: 4) A neuron with ionic gradients described in the table below receives a synaptic input that opens…

A: The formula to calculate sodium current is V = IR VOLATAGE POTENTIAL ( V) I - CURRENT R - RESISTANCE

Q: Channel labels Voltage-gated K* channels. Voltage-gated Na* channels Ligand-gated Na* channels.…

A: Nerve potentials. The ability of the nerve to generate the action potential on its membrane is known…

Q: If the postsynaptic cell's plasma membrane were to become substantially more permeable to Na+, you…

A: Action potential is the change in electrical potential associated with the passage of an impulse…