Based on the attached figure (Figure 7.14 in your textbook) describing a form of synaptic plasticity called long-term depression, what is the most DIRECT mechanism causing the postsynaptic neuron to decrease its response to glutamate? AMPA receptor LTD results from fewer AMPA receptors. Dendritic spine of Purkinje cell Na Voltage-gated Ca²¹ channel Na+ PKC Climbing fiber depolarizes membrane potential to open Ca2+ channels. Presynaptic terminal of parallel fiber S DAG Parallel fibers activate AMPA and mGluR. Glutamate Ca²+ Phospholipase C IP 3 IP 3 receptor Release PIP 2 Endoplasmic reticulum mGluR mbing fiber depolarizes mbrane potential to en Ca2+ channels. tage-gated channel 2+ Ca²+ Release 2+ Ca²+ Endoplasmic reticulum removal of AMPA receptors from the postsynaptic membrane. insertion of AMPA receptors into the postsynaptic membrane O increase in intracellular Ca2+ via voltage-gated Ca2+ channels O DAG- and Ca2+-mediated activation of PKC increase in intracellular Ca2+ via endoplasmic reticulum IP3 receptors
Based on the attached figure (Figure 7.14 in your textbook) describing a form of synaptic plasticity called long-term depression, what is the most DIRECT mechanism causing the postsynaptic neuron to decrease its response to glutamate? AMPA receptor LTD results from fewer AMPA receptors. Dendritic spine of Purkinje cell Na Voltage-gated Ca²¹ channel Na+ PKC Climbing fiber depolarizes membrane potential to open Ca2+ channels. Presynaptic terminal of parallel fiber S DAG Parallel fibers activate AMPA and mGluR. Glutamate Ca²+ Phospholipase C IP 3 IP 3 receptor Release PIP 2 Endoplasmic reticulum mGluR mbing fiber depolarizes mbrane potential to en Ca2+ channels. tage-gated channel 2+ Ca²+ Release 2+ Ca²+ Endoplasmic reticulum removal of AMPA receptors from the postsynaptic membrane. insertion of AMPA receptors into the postsynaptic membrane O increase in intracellular Ca2+ via voltage-gated Ca2+ channels O DAG- and Ca2+-mediated activation of PKC increase in intracellular Ca2+ via endoplasmic reticulum IP3 receptors
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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
Transcribed Image Text:Based on the attached figure (Figure 7.14 in your
textbook) describing a form of synaptic plasticity
called long-term depression, what is the most
DIRECT mechanism causing the postsynaptic
neuron to decrease its response to glutamate?
AMPA
receptor
LTD results
from fewer
AMPA receptors.
Dendritic
spine of
Purkinje cell
Na
Voltage-gated
Ca²¹ channel
Na+
PKC
Climbing fiber depolarizes
membrane potential to
open Ca2+ channels.
Presynaptic
terminal of
parallel fiber
S
DAG
Parallel fibers activate
AMPA and mGluR.
Glutamate
Ca²+
Phospholipase C
IP 3
IP 3 receptor
Release
PIP 2
Endoplasmic
reticulum
mGluR

Transcribed Image Text:mbing fiber depolarizes
mbrane potential to
en Ca2+ channels.
tage-gated
channel
2+
Ca²+
Release
2+
Ca²+
Endoplasmic
reticulum
removal of AMPA receptors from the postsynaptic membrane.
insertion of AMPA receptors into the postsynaptic membrane
O increase in intracellular Ca2+ via voltage-gated Ca2+ channels
O DAG- and Ca2+-mediated activation of PKC
increase in intracellular Ca2+ via endoplasmic reticulum IP3
receptors
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