The antidepressant amitriptyline inhibits the reuptake of norepinephrine and serotonin from the synaptic cleft. Because the reuptake of these neurotransmitters is inhibited, their effects are potentiated; they remain available to interact with serotonin and norepinephrine receptor sites longer and continue to cause excitation of sero- tonin- and norepinephrine-mediated neural pathways. Following is a synthesis for amitriptyline. H,PO, COOH (A) (B) HBr НО Br `NMe, (C) (D) Amitriptyline

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