A consumer survey has highlighted a major increase in the use of Pregabalin, an authorisedantiepileptic drug. The working hypothesis is that this drug is being used in other pathologies,such as to treat neuropathic pain. What sort of indicators could we use to obtain informationthat might enable us to test this hypothesis?Select one:O a. The conducting of a controlled clinical trial enabling us to assess the efficacy ofPregabalin in neuropathic pain.O b. The construction of drug-indication indicators (studying consumption in terms of theindication for which it is prescribed).O c. The construction of indicators that relate the drug to the indication and the treatmentoutcome.O d. A comparison between the consumption of Pregabalin in defined daily doses per 1000inhabitants per day and the diagnosed prevalence of epilepsy.

Asked : Indicatord used to obtain information to test hypothesis from the given options

Answered: A consumer survey has highlighted a…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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In 1993, Dr Knox Todd, an emergency physician on the medical staff of the UCLA Emergency Center in Los Angeles, reported study findings on a pain study. In the study, they looked at treatment given to all emergency department patients at UCLA between the ages of 15 and 55 over a two-year period for the treatment of an isolated long-bone fracture to arm or leg. They selected this injury because it is one of the most consistently painful. The patients had no other serious injuries. Given the community served, these patients were either Hispanic (31 patients) or White (108 patients). They found: - 17 of the 31 Hispanic patients (55%) received no medication for pain during treatment - 28 of the 108 White patients (26%) received no medication for pain during treatment Many professional colleagues criticized the study and suggested that different ethnic groups respond to pain differently. That Hispanic patients may be more stoic in the face of their injury, expressing fewer symptoms of pain…
None
3) Where is TTX obtained from? 4) What was the effect of Lidocaine? 5) Relate 4 above to Lidocaine's clinical use Activity 5: Measuring Refractory Periods of Neurons: this simulation you will gradually decrease the time between successive stimuli until: d. A stronger stimulus is required to generate a 2nd AP (relative refractory period) of b. A second AP cannot be produced at all (absolute refractory period). Use your data from Chart 5 to answer the questions below: 1) What interval between stimuli initially prevented a second AP? 2) Was this the relative or absolute refractory period? 3) What was the minimum interval for relative refractory period (hint: minimum interval where you could still generate a second AP with a stronger stimulus? 4) What interval completely prevented a second AP? 5) Is this relative or absolute RP? ME Activity 6: The "Language" of the nervous system: Frequency of Aps. Use your data from Chart 6 to answer the questions below: 1) What is the effect of…
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