Which statement best describes the physiological role of the endocannabinoid system in learning extinction?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Which statement best describes the physiological role of the endocannabinoid system in learning extinction?

(a) Activation of the CB1 receptor increases learning extinction;

(b) Activation of the CB1 receptor decreases learning extinction;

(c) Blockade of the CB1 receptor increases learning extinction;

(d) Blockade of the CB1 receptor decreases learning extinction.

Expert Solution
Extinction learning

Extinction learning is the phenomenon by which animals with advanced mental capabilities (like dogs, humans, etc) learn to stop responding to a conditioned stimulus, after the stimulus have stopped been followed by an expected outcome. 

Suppose you trained a dog from its childhood to come to you to feed whenever you ring a bell. So after ringing the bell, you used to feed the dog. But for a few weeks or even months, you rang the bell but did not feed the dog after. Gradually the dog will stop coming to you whenever you rang the bell. This phenomenon by which the dog learned to stop responding to the bell (the  stimulus) , after a period in which the bell was not followed by food (the expected outcome), is what is called extinction learning.

 

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