A confirmed case of systemic lupus erythematosus (SLE) with lupus associated nephritis has been admitted to the hospital. The follow-up ELISA to detect various autoantibodies suggests very high titres of anti-C1q autoantibodies. Explain How would you design your C1q-dependent haemolytic assay using this patient’s serum? How would you explain your results if you achieve a normal CH50 value? How would you explain your results if you fail to achieve a CH50 value
Proteins
We generally tend to think of proteins only from a dietary lens, as a component of what we eat. However, they are among the most important and abundant organic macromolecules in the human body, with diverse structures and functions. Every cell contains thousands and thousands of proteins, each with specific functions. Some help in the formation of cellular membrane or walls, some help the cell to move, others act as messages or signals and flow seamlessly from one cell to another, carrying information.
Protein Expression
The method by which living organisms synthesize proteins and further modify and regulate them is called protein expression. Protein expression plays a significant role in several types of research and is highly utilized in molecular biology, biochemistry, and protein research laboratories.
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A confirmed case of systemic lupus erythematosus (SLE) with lupus associated nephritis has been admitted to the hospital. The follow-up ELISA to detect various autoantibodies suggests very high titres of anti-C1q autoantibodies. Explain
How would you design your C1q-dependent haemolytic assay using this patient’s serum?
How would you explain your results if you achieve a normal CH50 value?
How would you explain your results if you fail to achieve a CH50 value?
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