Column A Column B a. tumor-associated 1. more resistant to antigens chemotherapy and radiation than tumor cells b. peptide splicing 2. novel peptide antigens arising from viruses, genomic and protein alterations, aberrant MRNA splicing, and peptide splicing c. cancer stem cells 3. formation of peptide bonds in the proteasome producing a non-contiguous amino acid sequence not found in the |native protein | 4. arise from reactivation of normally silenced genes or overexpression of genes d. soluble MIC glycoproteins e. tumor-specific antigens 5. enhance removal of NKG2D from lymphocyte surfaces

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