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A certain metabolic pathway can be diagrammed as: X Y A B C D where A, B, C, and D are the metabolic intermediates and X, Y, and Z are the enzymes responsible for each conversion. The physiological free energies for each enzyme catalyzed reaction are: AG = -0.2 kJ/mol X Y AG' = -1.3 kJ/mol ZAG' = -12.3 kJ/mol a. Which reaction likely represents a major regulatory point for this pathway? b. If your answer for part a. was, in fact, the case, if an inhibitor of Enzyme Z was present, would the concentrations of metabolites A, B, C, and D be increased, decreased, or not affected? c. Identify which of the enzymes X, Y, and 2, if any, would likely need to be bypassed for the metabolite D to be converted to A.

A certain metabolic pathway can be diagrammed as: X Y A B C D where A, B, C, and D are the metabolic intermediates and X, Y, and Z are the enzymes responsible for each conversion. The physiological free energies for each enzyme catalyzed reaction are: AG = -0.2 kJ/mol X Y AG' = -1.3 kJ/mol ZAG' = -12.3 kJ/mol a. Which reaction likely represents a major regulatory point for this pathway? b. If your answer for part a. was, in fact, the case, if an inhibitor of Enzyme Z was present, would the concentrations of metabolites A, B, C, and D be increased, decreased, or not affected? c. Identify which of the enzymes X, Y, and 2, if any, would likely need to be bypassed for the metabolite D to be converted to A.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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A certain metabolic pathway can be diagrammed as: X Y Z A B C D C²D where A, B, C, and D are the metabolic intermediates and X, Y, and Z are the enzymes responsible for each conversion. The physiological free energies for each enzyme catalyzed reaction are: X AG = -0.2 kJ/mol Y AG¹ = -1.3 kJ/mol ZAG' = -12.3 kJ/mol a. Which reaction likely represents a major regulatory point for this pathway? b. If your answer for part a. was, in fact, the case, if an inhibitor of Enzyme Z was present, would the concentrations of metabolites A, B, C, and D be increased, decreased, or not affected? c. Identify which of the enzymes X, Y, and Z, if any, would likely need to be bypassed for the metabolite D to be converted to A.
Transcribed Image Text:A certain metabolic pathway can be diagrammed as: X Y Z A B C D C²D where A, B, C, and D are the metabolic intermediates and X, Y, and Z are the enzymes responsible for each conversion. The physiological free energies for each enzyme catalyzed reaction are: X AG = -0.2 kJ/mol Y AG¹ = -1.3 kJ/mol ZAG' = -12.3 kJ/mol a. Which reaction likely represents a major regulatory point for this pathway? b. If your answer for part a. was, in fact, the case, if an inhibitor of Enzyme Z was present, would the concentrations of metabolites A, B, C, and D be increased, decreased, or not affected? c. Identify which of the enzymes X, Y, and Z, if any, would likely need to be bypassed for the metabolite D to be converted to A.
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