A 55 year old man with history of coronary artery disease and diabetes mellitus type 2 is hospitalized following an above-the-knee amputation. A CBC finds mild anemia and thrombocytopenia with a mildly elevated WBC and differential. A tech is reviewing his smear and brings a slide to you because the "neutrophils look strange." You look at the smear and see that almost all neutrophils have the appearance of those in this image. What is the most likely diagnosis?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A 55 year old man with history of coronary artery disease and diabetes mellitus type 2 is
hospitalized following an above-the-knee amputation. A CBC finds mild anemia and
thrombocytopenia with a mildly elevated WBC and differential. A tech is reviewing his smear
and brings a slide to you because the "neutrophils look strange." You look at the smear and see
that almost all neutrophils have the appearance of those in this image. What is the most likely
diagnosis?
A. Pelger Huët anomaly
B. Hemophagocytic lymphohistiocytosis
C. Chediak-Higashi syndrome
OD. Megaloblastic anemia
OE. May-Hegglin anomaly
Transcribed Image Text:A 55 year old man with history of coronary artery disease and diabetes mellitus type 2 is hospitalized following an above-the-knee amputation. A CBC finds mild anemia and thrombocytopenia with a mildly elevated WBC and differential. A tech is reviewing his smear and brings a slide to you because the "neutrophils look strange." You look at the smear and see that almost all neutrophils have the appearance of those in this image. What is the most likely diagnosis? A. Pelger Huët anomaly B. Hemophagocytic lymphohistiocytosis C. Chediak-Higashi syndrome OD. Megaloblastic anemia OE. May-Hegglin anomaly
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