77 10 9 The following 5 population genetics questions refer to this introduction: "Tay-Sachs disease is inherited as an autosomal recessive, caused by the absence of hexosaminidase-A (Hex-A). Without Hex-A a lipid accumulates in cells, particularly in the brain, resulting in homozygous re individuals regressing in mental and physical function until death in early childhood. Heterozygotes have abnormal Hex-A activity but manifest no disease symptoms. In a large eastern European population, the of Tay-Sachs disease is 3 percent. Using this information answer the following." a) If the population is assumed to be in Hardy-Weinberg equilibrium with respect to Tay-Sachs, what is the frequency of the allele that causes Tay-Sachs (answer in two decimal points [DP])? b) What would be the frequency of heterozygotes (answer in 2 DP)? Asse c) Assuming no assortative mating, what is the probability of two heterozygotes mating (answer in 2DP)? d) In children of such marriages, what would be the frequency of Tay-Sachs disease (answer in 2DP)? e) What proportion of all Tay-Sachs births are produced by such marriages (answer in 2DP)? 10 1 15 16 20 21

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Communication

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