17,18 Spondylocostal dysostosis is a disabling autosomal recessive disorder withcharacteristics including short thorax, short neck with limited mobility, wingedscapulae and scoliosis. In a Swiss village of 1,000 people, 50 people havespondylocostal dysostosis. How many people do you estimate to be non-carriersfor this disease (i.e. homozygous for the dominant allele)? Assume thepopulation is in Hardy-Weinberg equilibrium.224776174603348 Apart from this one village, elsewhere in Switzerland the frequency ofindividuals with spondylocostal dysostosis is much lower, around 5/1000people. Which of the following is the most likely explanation for the highfrequency in the village described in the previous question?Positive selection increased the frequency of the spondylocostal dysostosis allele inthe village relative to the general Swiss populationNegative selection decreased the frequency of the spondylocostal dysostosis allele inthe village relative to the general Swiss populationInbreeding within the village increased the frequency of the spondylocostal dysostosisallele in the village relative to the general Swiss populationThe village was founded by a small number of individuals with an unusually highfrequency of spondylocostal dysostosis carriers

Name: 17,18 Spondylocostal dysostosis is a disabling autosomal recessive dis
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Description: 17,18 Spondylocostal dysostosis is a disabling autosomal recessive disorder withcharacteristics including short thorax, short neck with limited mobility, wingedscapulae and scoliosis. In a Swiss village of 1,000 people, 50 people havespondylocostal d

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BIOLOGY:CONCEPTS+APPL.(LOOSELEAF)

10th Edition

ISBN:9781305967359

Author:STARR

Publisher:STARR

Chapter14: Human Inheritance

Section: Chapter Questions

Problem 4GP: An allele responsible for Marfan syndrome Section 13.4 is inherited in an autosomal dominant...

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17,18

Spondylocostal dysostosis is a disabling autosomal recessive disorder with
characteristics including short thorax, short neck with limited mobility, winged
scapulae and scoliosis. In a Swiss village of 1,000 people, 50 people have
spondylocostal dysostosis. How many people do you estimate to be non-carriers
for this disease (i.e. homozygous for the dominant allele)? Assume the
population is in Hardy-Weinberg equilibrium.
224
776
174
603
348

Apart from this one village, elsewhere in Switzerland the frequency of
individuals with spondylocostal dysostosis is much lower, around 5/1000
people. Which of the following is the most likely explanation for the high
frequency in the village described in the previous question?
Positive selection increased the frequency of the spondylocostal dysostosis allele in
the village relative to the general Swiss population
Negative selection decreased the frequency of the spondylocostal dysostosis allele in
the village relative to the general Swiss population
Inbreeding within the village increased the frequency of the spondylocostal dysostosis
allele in the village relative to the general Swiss population
The village was founded by a small number of individuals with an unusually high
frequency of spondylocostal dysostosis carriers

Expert Solution

Step 1: Spondylocostal dysostosis

Q17)

Spondylocostal dysostosis is a condition that occurs from birth and is characterized by abnormalities, in the spine and ribs. The main features typically include;

Shortened Chest; People with this condition have a chest, which can impact lung and heart function.
Limited Neck Mobility; They may have a neck with limited movement.
Protruding Shoulder Blades; The shoulder blades may stick out or appear "winged" from the back.
Sideways Curvature of the Spine; Scoliosis, a sideways curve of the spine is commonly seen in individuals with this disorder.
This disorder follows a pattern meaning that affected individuals inherit two copies of the mutated gene, one from each parent. The severity of symptoms can vary among individuals.
The management of dysostosis often involves addressing symptoms and may include surgical interventions to correct spinal or chest wall deformities. Early diagnosis and medical care play a role, in managing this condition

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