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6. Retinal is a conjugated chromophore that is responsible for our ability to see. Retinal is covalently bound to the protein Rhodopsin through a lysine residue. CHO Rhodopsin |NH2 + 6.1 Draw a non-enzymatic mechanism to describe the formation of the imine between retinal and lysine. For simplicity, use R-NH2 to represent lysine. 6.2 During the visual cycle, retinal absorbs a photon and this leads to a conformation change. The bond between retinal and the protein is hydrolyzed and retinal is disconnected from the protein. Draw an arrow-pushing mechanism describing this hydrolysis step (remember that this is the reverse reaction for imine formation).

6. Retinal is a conjugated chromophore that is responsible for our ability to see. Retinal is covalently bound to the protein Rhodopsin through a lysine residue. CHO Rhodopsin |NH2 + 6.1 Draw a non-enzymatic mechanism to describe the formation of the imine between retinal and lysine. For simplicity, use R-NH2 to represent lysine. 6.2 During the visual cycle, retinal absorbs a photon and this leads to a conformation change. The bond between retinal and the protein is hydrolyzed and retinal is disconnected from the protein. Draw an arrow-pushing mechanism describing this hydrolysis step (remember that this is the reverse reaction for imine formation).

Organic Chemistry
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter18: Functional Derivatives Of Carboxylic Acids
Section18.8: Interconversion Of Functional Derivatives
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6. Retinal is a conjugated chromophore that is responsible for our ability to see. Retinal is covalently bound to the protein Rhodopsin through a lysine residue. CHO Rhodopsin |NH2 + 6.1 Draw a non-enzymatic mechanism to describe the formation of the imine between retinal and lysine. For simplicity, use R-NH2 to represent lysine. 6.2 During the visual cycle, retinal absorbs a photon and this leads to a conformation change. The bond between retinal and the protein is hydrolyzed and retinal is disconnected from the protein. Draw an arrow-pushing mechanism describing this hydrolysis step (remember that this is the reverse reaction for imine formation).
Transcribed Image Text:6. Retinal is a conjugated chromophore that is responsible for our ability to see. Retinal is covalently bound to the protein Rhodopsin through a lysine residue. CHO Rhodopsin |NH2 + 6.1 Draw a non-enzymatic mechanism to describe the formation of the imine between retinal and lysine. For simplicity, use R-NH2 to represent lysine. 6.2 During the visual cycle, retinal absorbs a photon and this leads to a conformation change. The bond between retinal and the protein is hydrolyzed and retinal is disconnected from the protein. Draw an arrow-pushing mechanism describing this hydrolysis step (remember that this is the reverse reaction for imine formation).
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