6. Retinal is a conjugated chromophore that is responsible for our ability to see. Retinal is covalently bound to the protein Rhodopsin through a lysine residue. CHO Rhodopsin |NH2 + 6.1 Draw a non-enzymatic mechanism to describe the formation of the imine between retinal and lysine. For simplicity, use R-NH2 to represent lysine. 6.2 During the visual cycle, retinal absorbs a photon and this leads to a conformation change. The bond between retinal and the protein is hydrolyzed and retinal is disconnected from the protein. Draw an arrow-pushing mechanism describing this hydrolysis step (remember that this is the reverse reaction for imine formation).
6. Retinal is a conjugated chromophore that is responsible for our ability to see. Retinal is covalently bound to the protein Rhodopsin through a lysine residue. CHO Rhodopsin |NH2 + 6.1 Draw a non-enzymatic mechanism to describe the formation of the imine between retinal and lysine. For simplicity, use R-NH2 to represent lysine. 6.2 During the visual cycle, retinal absorbs a photon and this leads to a conformation change. The bond between retinal and the protein is hydrolyzed and retinal is disconnected from the protein. Draw an arrow-pushing mechanism describing this hydrolysis step (remember that this is the reverse reaction for imine formation).
Chapter26: Biomolecules: Amino Acids, Peptides, And Proteins
Section26.SE: Something Extra
Problem 50AP: The -helical parts of myoglobin and other proteins stop whenever a proline residue is encountered in...
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Transcribed Image Text:6. Retinal is a conjugated chromophore that is responsible for our ability to see. Retinal is
covalently bound to the protein Rhodopsin through a lysine residue.
CHO
Rhodopsin |NH2
+
6.1 Draw a non-enzymatic mechanism to describe the formation of the imine between
retinal and lysine. For simplicity, use R-NH2 to represent lysine.
6.2 During the visual cycle, retinal absorbs a photon and this leads to a conformation change.
The bond between retinal and the protein is hydrolyzed and retinal is disconnected from
the protein. Draw an arrow-pushing mechanism describing this hydrolysis step
(remember that this is the reverse reaction for imine formation).
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