5-6. Choose the best answer from the following questions and provide a one paragraph explanation for yourresponse.5. Since in this patient pyruvate kinase is abnormal not only is less pyruvate made but intermediates abovepyruvate in the glycolytic pathway build up slowing the pathway. Which of the following products may not bemade in the appropriate amounts in the RBC because of the deficiency of pyruvateA. Glucose?B. OxaloacetateC. acetyl-CoAD. LactateExplanation for answer in no. 5:6. In the RBCS of the patient described above, which of the following would be expectedA. ADP to ATP ratios would be elevated above normal.B. NADP+ would increase relative to NADPH.?C. Ribulose 5-phosphate levels would decrease.D. NADH to NAD+ ratios would decrease.E. Methemoglobin levels would increase.Explanation for answer in no. 6:

“Since you have asked multiple questions, we will solve the first question for you. If you want any…

Answered: 5. Since in this patient pyruvate…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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2.JThe fetal HbF has a higher affinity for oxygen than the mother HbA. What structural features of these protcins determine their difference in the ability to bind oxygen and what role does 2,3-bisphosphoglycerate play in this? What is the physiological mcaning of the different affinitics of these Hb forms for oxygen?
9. Which of the following enzymes CANNOT be found in the skeletal muscle? A. Glucose-6-phosphatase B. Glycogen synthase C. Glycogen phosphorylase D. Adenylyl cyclase E. Hexokinase 10. Which of the following processes do NOT produce CO2? (1) Fatty acid synthesis (2) Oxidative deamination (3) Preparatory phase of glycolysis (4) Pentose phosphate pathway A. (1) and (2) only B. (2) and (3) only C. (2) and (4) only D. (1), (3) and (4) only E. (1), (2), (3) and (4) 11. is an intermediate metabolite linkage between carbohydrate and fat metabolism. A. Malate B. Citrate C. Acetyl-CoA D. Aspartate E. a-ketoglutarate 12. transfers carnitine from mitochondrial matrix to cytoplasm during the transport of fatty acid to mitochondria. A. Carnitine acyltransferase I B. Carnitine acyltransferase II C. Transaminase D. Translocase E. Citric acid shuttle 13. Which of the following reactions/ pathways does NOT produce NADH? A. Payoff phase of glycolysis B. Oxidative deamination of glutamine C. B-oxidation…
Toxic hydrogen peroxides resulting from intracellular oxidation reactions are catabolized by peroxisomes producing: a.ATPase b.Kinesin c.Catalase d.Kinase e.Polymerase
3. In your textbook the termi- nal enzyme catalyzing the ter- minal step of glycolysis is known as pyruvate kinase (PK). No indication is given that in mammalian tissues there are four different iso- forms of this enzyme. The four mammalian isoforms are known as PKL, PKR, PKM1 and PKM2. PKL is expressed in the liver, and PKR is ex- pressed in red blood cells. C PKM1 and PKM2 are derived from altemative splicing of the PKM gene. PKM1 is a constitu- tively active isoform expressed Active Site A PKM2 Monomer B Fructose-1,6-Bisphosphate N Phe, Ala, Ser Binding Site PKM2 Tetramer "Activator" Binding Site in differentiated cells from various tissues. In contrast, PKM2 has low basal activity and is activated by an effector molecule fructose 1,6-bisphosphate (FBP). PKM2 is expressed in most proliferating cells. In addition, the regulation of PKM2 pyruvate kinase activity plays an essential role in cancer metabolism and is crucial for the growth and survival of cancer cells. Recently, PKM2 has…
………….. is associated with low serum iron and high total iron-binding capacity (TIBC) A. Megaloblastic anemia (macrocytic) B. Iron intoxication C. Hemosiderosis D. Microcytic hypochromic anemia E. None of the above
Vitamin B12 cannot be produced by the human body but instead must be obtained from your diet. A patient has a diagnosis of pernicious anemia (Megaloblastic anemia). Explain the most common underlying cause of this disorder and explain how it is treated?
6. Provide a biochemical explanation for the fact that some patients with homocystinuria respond to vitamin Bo, while others do not. 7. In addition to the reaction shown in the metabolic pathway, vitamin Bo participates in a considerable number of other metabolic reactions of amino acids. Why does the daily requirement for vitamin Be vary according to the amount of protein in the diet? 1.
One of the following is NOT correct regards haptoglobin A. is a strong acute-phase protein, increases 1000-folds shortly after inflammation B. is α2-glycoprotein C. Prevents iron loss through the kidneys D. is decreased in liver disease and haemolytic anemia E. None of the above
4. If lots of acetyl-CoA is being formed in the mitochondrial matrix, a particular compound will be exported into the cytosol. a.What compound is this? b. What effect does this compound have on fatty acid synthesis? c. How does the compound produce this effect?
Platelets from a patient with long bleeding times are tested in vitro and shown to display reduced adhesion and aggregation responses to collagen. What mechanisms could account for the altered in vitro responses and haemostaticn phenotype this is from a past paper but i couldnt find an example answer
3. In your textbook the termi- nal enzyme catalyzing the ter- minal step of glycolysis is known as pyruvate kinase (PK). No indication is given that in mammalian tissues there are four different iso- forms of this enzyme. The four mammalian isoforms are known as PKL, PKR, PKM1 and PKM2. PKL is expressed in the liver, and PKR is ex- pressed in red blood cells. C PKM1 and PKM2 are derived from altemative splicing of the PKM gene. PKM1 is a constitu- tively active isoform expressed Active Site A PKM2 Monomer B Fructose-1,6-Bisphosphate N Phe, Ala, Ser Binding Site PKM2 Tetramer "Activator" Binding Site in differentiated cells from various tissues. In contrast, PKM2 has low basal activity and is activated by an effector molecule fructose 1,6-bisphosphate (FBP). PKM2 is expressed in most proliferating cells. In addition, the regulation of PKM2 pyruvate kinase activity plays an essential role in cancer metabolism and is crucial for the growth and survival of cancer cells. Recently, PKM2 has…
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