Answered: 5. Hemophilia is caused by an X-linked…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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My Question is what is the probability their first child will have hemophilia and drawn pedigrees for family members with genotypes.

My explantion so far:

A man has both X and Y chromosomes as sex chromosomes in his body. Here, though the brother of the man is hemophiliac, a man can’t be a carrier of hemophilia. So, it can be said that his chromosome is “XnY”.Here, the “n” stands for “normal”.Though the paternal uncle is hemophiliac, a man cannot be a carrier of hemophilia, his niece will not be a career. So it can be said that the woman is also not a carrier and has the “XnX” chromosome.So, as the mother is not a carrier, their first child does not have a chance of having hemophilia. This can be determined as it is known that there is no hidden carrier of hemophilia in the family.

Paternal un cle
Brother
Xn Y
し
Niece
Brother
メーメ
メーY
メッx/xmY
First child
Here h stands for haemophiliac
sta nds for normal
the know n
Figure- Pedigree of
people in the fami lies.

5. Hemophilia is caused by an X-linked recessive mutation in humans. If a woman whose paternal
uncle (father's brother) was a hemophiliac marries a man whose brother is also a hemophiliac,
what is the probability that their first child will have hemophilia? (Assume that no other cases of
hemophilia and no hidden carriers exist in the family.) Draw the pedigree of the known people in
the families along with the genotypes to show how you are able to calculate the probability.

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