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5. For each of the following tables, indicate all of the possibilities from the list that might explain the dose- or concentration-dependent kinetics observed for each substance, administered to the same. Each scenario has at least one but no more than three correct answers. List of Explanations 1. Saturated plasma protein binding. II. Saturation of hepatic metabolism. III. Saturation of active tubular secretion. IV. Saturation of active tubular reabsorption. V. Saturation of P-glycoprotein pumps. a) Total bioavailability with increasing oral dose of xenobiotic Area under curve Single oral dose (mg) 125 250 500 1000 (plasma concentration versus time) 62 121 294 804 Possible explanations: b) Biliary elimination with increasing dose: Single sublingual dose (mg) Amount (mg) excreted unchanged in 48hr 100 11.1 200 19.8 400 21.2 Possible explanations: c) Steady-state plasma concentration with increasing rate of infusion IV infusion dose rate (mg/hr) Steady-state plasma concentration (mg/L) 50 100 200 6 11 14 Possible explanations: 9

5. For each of the following tables, indicate all of the possibilities from the list that might explain the dose- or concentration-dependent kinetics observed for each substance, administered to the same. Each scenario has at least one but no more than three correct answers. List of Explanations 1. Saturated plasma protein binding. II. Saturation of hepatic metabolism. III. Saturation of active tubular secretion. IV. Saturation of active tubular reabsorption. V. Saturation of P-glycoprotein pumps. a) Total bioavailability with increasing oral dose of xenobiotic Area under curve Single oral dose (mg) 125 250 500 1000 (plasma concentration versus time) 62 121 294 804 Possible explanations: b) Biliary elimination with increasing dose: Single sublingual dose (mg) Amount (mg) excreted unchanged in 48hr 100 11.1 200 19.8 400 21.2 Possible explanations: c) Steady-state plasma concentration with increasing rate of infusion IV infusion dose rate (mg/hr) Steady-state plasma concentration (mg/L) 50 100 200 6 11 14 Possible explanations: 9

Chemistry for Today: General, Organic, and Biochemistry
Chemistry for Today: General, Organic, and Biochemistry
9th Edition
ISBN:9781305960060
Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Chapter25: Body Fluids
Section: Chapter Questions
Problem 25.56E
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5. For each of the following tables, indicate all of the possibilities from the list that might explain the dose- or concentration-dependent kinetics observed for each substance, administered to the same. Each scenario has at least one but no more than three correct answers. List of Explanations 1. Saturated plasma protein binding. II. Saturation of hepatic metabolism. III. Saturation of active tubular secretion. IV. Saturation of active tubular reabsorption. V. Saturation of P-glycoprotein pumps. a) Total bioavailability with increasing oral dose of xenobiotic Area under curve Single oral dose (mg) 125 250 500 1000 (plasma concentration versus time) 62 121 294 804 Possible explanations: b) Biliary elimination with increasing dose: Single sublingual dose (mg) Amount (mg) excreted unchanged in 48hr 100 11.1 200 19.8 400 21.2 Possible explanations: c) Steady-state plasma concentration with increasing rate of infusion IV infusion dose rate (mg/hr) Steady-state plasma concentration (mg/L) 50 100 200 6 11 14 Possible explanations: 9
Transcribed Image Text:5. For each of the following tables, indicate all of the possibilities from the list that might explain the dose- or concentration-dependent kinetics observed for each substance, administered to the same. Each scenario has at least one but no more than three correct answers. List of Explanations 1. Saturated plasma protein binding. II. Saturation of hepatic metabolism. III. Saturation of active tubular secretion. IV. Saturation of active tubular reabsorption. V. Saturation of P-glycoprotein pumps. a) Total bioavailability with increasing oral dose of xenobiotic Area under curve Single oral dose (mg) 125 250 500 1000 (plasma concentration versus time) 62 121 294 804 Possible explanations: b) Biliary elimination with increasing dose: Single sublingual dose (mg) Amount (mg) excreted unchanged in 48hr 100 11.1 200 19.8 400 21.2 Possible explanations: c) Steady-state plasma concentration with increasing rate of infusion IV infusion dose rate (mg/hr) Steady-state plasma concentration (mg/L) 50 100 200 6 11 14 Possible explanations: 9
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