5 3 3 5 T-A G-C C-G C-G T-A G-C 3' G-C T•A-T T•A-T T.A-T T•A-T T•A-T C+G-C T.A-T T•A-T T•A-T C+G-C T.A-T T•A-T C+G-C T•A-T T•A-T T•A-T T.A-T C+G-C T•A-T T•A-T 5' G-C G-C 3' C-G з 5 (b) Example sequence of bases (a) Ribbon model FIGURE 9.15 The structure oftriplex DNA. (a) As seen in the ribbon model, the third, synthetic strand binds within the major groove of the double-stranded structure. (b) Within triplex DNA, the third strand hydrogen bonds according to the rule T to AT, and C to GC. The cy tosine bases in the third strand are protonated (i.c., positively charged).

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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On further analysis of the DNA described in conceptual question
C21, you discover that the triplex DNA in this alien organism is
composed of a double helix with a third strand wound within the
major groove (just like the DNA in Figure shown). How would you
propose that this DNA is able to replicate itself? In your answer,
be specific about the base-pairing rules within the double helix
and which part of the triplex DNA would be replicated first.

5 3
3 5
T-A
G-C
C-G
C-G
T-A
G-C
3' G-C
T•A-T
T•A-T
T.A-T
T•A-T
T•A-T
C+G-C
T.A-T
T•A-T
T•A-T
C+G-C
T.A-T
T•A-T
C+G-C
T•A-T
T•A-T
T•A-T
T.A-T
C+G-C
T•A-T
T•A-T
5' G-C
G-C
3'
C-G
з 5
(b) Example sequence
of bases
(a) Ribbon model
FIGURE 9.15 The structure oftriplex DNA. (a) As seen in the
ribbon model, the third, synthetic strand binds within the major groove of
the double-stranded structure. (b) Within triplex DNA, the third strand
hydrogen bonds according to the rule T to AT, and C to GC. The cy tosine
bases in the third strand are protonated (i.c., positively charged).
Transcribed Image Text:5 3 3 5 T-A G-C C-G C-G T-A G-C 3' G-C T•A-T T•A-T T.A-T T•A-T T•A-T C+G-C T.A-T T•A-T T•A-T C+G-C T.A-T T•A-T C+G-C T•A-T T•A-T T•A-T T.A-T C+G-C T•A-T T•A-T 5' G-C G-C 3' C-G з 5 (b) Example sequence of bases (a) Ribbon model FIGURE 9.15 The structure oftriplex DNA. (a) As seen in the ribbon model, the third, synthetic strand binds within the major groove of the double-stranded structure. (b) Within triplex DNA, the third strand hydrogen bonds according to the rule T to AT, and C to GC. The cy tosine bases in the third strand are protonated (i.c., positively charged).
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