An article entitled “Nucleosome Positioning at the Replication Fork” states: “both the ‘old’ randomly segregated nucleosomes as well as the ‘new’ assembled histone octamers rapidly position themselves (within seconds) on the newly replicated DNA strands” [Lucchini et al. (2002)]. Given this statement, how would one compare the distribution of nucleosomes and DNA in newly replicated chromatin? How could one experimentally test the distribution of nucleosomes on newly replicated chromosomes?

Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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An article entitled “Nucleosome Positioning at the Replication
Fork” states: “both the ‘old’ randomly segregated nucleosomes
as well as the ‘new’ assembled histone octamers rapidly position
themselves (within seconds) on the newly replicated DNA strands”
[Lucchini et al. (2002)]. Given this statement, how would one compare
the distribution of nucleosomes and DNA in newly replicated
chromatin? How could one experimentally test the distribution of
nucleosomes on newly replicated chromosomes?

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