45. Receptor tyrosine kinases (RTK)s are the high-affinity cell surface receptors for manypolypeptide growth factors, cytokines, and hormones. The following statements are aboutreceptor tyrosine kinases.A. Receptor tyrosine kinases will undergo conformational changes upon binding of ligands, butcannot move across cell membranes upon binding of ligands.B. Receptor tyrosine kinases can bind certain protein phosphatases.C. Receptor tyrosine kinases can only phosphorylate themselves (called autophosphorylation)but do not phosphorylate other proteins/enzymes.D. Receptor tyrosine kinases phosphorylate one or more specific tyrosine residues, but not alltyrosine residues of a particular protein.The correct statement(s) is(are):a) only A andDb) only B and Cc) only B and Dd) only A, B and De) All of themYour answer:luoore is a nolar

The correct statements are: Option d. Only A, B and D.

Answered: 45. Receptor tyrosine kinases (RTK)s…

Biochemistry

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ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

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Problem 1P

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A tumor cannot grow to be very large without the development of new blood vessels (angiogenesis) to provide access to oxygen and nutrients. During the 1990s, it was discovered that Factor X stimulates the proliferation and migration of the cells that form blood vessels, thereby inducing the formation of new blood vessels. Factor X binds to specific receptor tyrosine kinases (RTKs) on the cell surface and causes the RTKs to dimerize and become active, initiating an intracellular signaling cascade that stimulates cell division and inhibits apoptosis. Many cancer cells secrete high levels of Factor X, and increased Factor X expression in a tumor is correlated with a poor medical outcome for the patient. Some evidence suggests that blocking Factor X-dependent signaling may prevent the formation of new blood vessels and lead to the death of immature blood vessels without disturbing mature blood vessels. You work for a biotechnology company that seeks to create anticancer drugs that…
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45. Receptor tyrosine kinases (RTK)s are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. The following statements are about