Answered: 38. Adenosine deaminase acting on RNA… | bartleby

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

38. Adenosine deaminase acting on RNA
(ADARS) catalyzes the conversion of
Adenosine to Inosine (at right). This is an
RNA editing enzyme. Why does A to I
editing destabilize duplex RNA? Draw out
how inosine could base pair with cytosine
(Draw hydrogen bonds as dashed lines,
and draw hydrogen atoms involved in
hydrogen bonds. Indicate the position of the ribose with an "R" (you do not need to draw
the ribose).
ADAR
NH2 Editing
N-
enzyme
N-
NH
N.
N.
N.
RNA
RNA
Adenosine
Inosine

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