3. Among the steps for the synthesis of asymmetric 1,4-dihydropiridines, a fundamental intermediate in the synthesis of pyridinic heterocycles, the main step is the aldol condensation between an aldehyde and a-ketoester, this is the first step in the Hantzsch synthesis. Indicate the starting products and perform the mechanism to obtain the first aldol condensation product to obtain the calcium channel blocker nivaldipine. OCH3 H2N. OCH3 H OCH3 CH3- N. OCH3 LOCH3 LOCH3 CH3- CH3 Ô `NO2 CH3: H. CN CH3- CHO HCI NH2OH CH3: LOCH3 CH3: LOCH3 (CH3CO)20 CH3 Ö CH3 Ö 'NO2 `NO2 nilvadipina
3. Among the steps for the synthesis of asymmetric 1,4-dihydropiridines, a fundamental intermediate in the synthesis of pyridinic heterocycles, the main step is the aldol condensation between an aldehyde and a-ketoester, this is the first step in the Hantzsch synthesis. Indicate the starting products and perform the mechanism to obtain the first aldol condensation product to obtain the calcium channel blocker nivaldipine. OCH3 H2N. OCH3 H OCH3 CH3- N. OCH3 LOCH3 LOCH3 CH3- CH3 Ô `NO2 CH3: H. CN CH3- CHO HCI NH2OH CH3: LOCH3 CH3: LOCH3 (CH3CO)20 CH3 Ö CH3 Ö 'NO2 `NO2 nilvadipina
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter10: Alcohols
Section: Chapter Questions
Problem 10.57P
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