3. Among the steps for the synthesis of asymmetric 1,4-dihydropiridines, a fundamental intermediate in the synthesis of pyridinic heterocycles, the main step is the aldol condensation between an aldehyde and a-ketoester, this is the first step in the Hantzsch synthesis. Indicate the starting products and perform the mechanism to obtain the first aldol condensation product to obtain the calcium channel blocker nivaldipine. OCH3 H2N. OCH3 H OCH3 CH3- N. OCH3 LOCH3 LOCH3 CH3- CH3 Ô `NO2 CH3: H. CN CH3- CHO HCI NH2OH CH3: LOCH3 CH3: LOCH3 (CH3CO)20 CH3 Ö CH3 Ö 'NO2 `NO2 nilvadipina

3. Among the steps for the synthesis of asymmetric 1,4-dihydropiridines, a fundamental intermediate in the synthesis of pyridinic heterocycles, the main step is the aldol condensation between an aldehyde and a-ketoester, this is the first step in the Hantzsch synthesis. Indicate the starting products and perform the mechanism to obtain the first aldol condensation product to obtain the calcium channel blocker nivaldipine. OCH3 H2N. OCH3 H OCH3 CH3- N. OCH3 LOCH3 LOCH3 CH3- CH3 Ô `NO2 CH3: H. CN CH3- CHO HCI NH2OH CH3: LOCH3 CH3: LOCH3 (CH3CO)20 CH3 Ö CH3 Ö 'NO2 `NO2 nilvadipina

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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