2. Within a cellular environment, draw the sequence of events that occur whenextracellular LDL binds to the LDL receptor through generation ofcholesterol. Represent the sequence of events numerically. Label all relevantcellular structures.Details to include:components of the endocytic pathway and the pH of the compartmentsrepresentation of the LDL binding domain and beta-propeller domain of theLDL receptor.Conformation of LDL receptorUse a "+"to indicate when histidine(s) become protonated on the LDLreceptor.V-ATPases

Answered: Image /qna-images/answer/edd9127b-caeb-4d80-a740-dd029c635b14.jpg

Answered: 2. Within a cellular environment, draw…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Similar questions

Interpret the figure: Which enzyme generates A. lecanora hydrolysates with the highest ACE inhibitory activity? Does extended hydrolysis time affect ACE inhibition?
1. 65 years old woman with low physical activity got the excess carbohydrates (about 400 g daily) for several years. The laboratory value of total cholesterol in serum blood was 260 mg/dl. Why the excess consumption of carbohydrates can cause hypercholesterolemia? To answer the question: a) compare the cholesterol concentration in the serum blood of the patient with the normal range; b) draw the schemes of the metabolic pathways confirming that overeating of carbohydrates can result in hypercholesterolemia; c) draw the scheme of the cholesterol synthesis regulation; d) give your prescriptions for the diet and treatment of the patient.
1E. Please help me in detail
S-adenosylmethionine is an activated carrier molecule that transfers which of the following groups? the carboxylic acid group (with one carbon) the phosphate group (with zero carbons) the glucose group (with six carbons) the methyl group (with one carbon) the acetyl group (with two carbons)
2. Provide a short phrase or word to anwer each of the following: (a) What is the organ where glycogen is stored in humans? (b) What type of enzyme digests carbohydrates? (c) What is the name of the pathway that corresponds to Stage 2 for lipids? (d) Name the pathway that corresponds to Stage 3, assuming aerobic conditions (e) Name the pathway that transforms pyruvate into ethanol and carbon dioxide (f) What is the number of reactions in glycolysis? (g) What is the net gain of ATP in glycolysis? (h) Name the product when pyruvate is metabolized anaerobically.
3. The image below depicts 2,3-bisphosphoglycerate depicted in dark gray, and ß subunits are depicted in light gray. (BPG) bound to hemoglobin. The a subunits are BPG (a) Briefly explain how BPG regulates oxygen transport by hemoglobin and describe the critical chemical properties of BPG and its binding pocket.
9. In E. coli the synthesis of phosphatidylethanolamine directly involves: acyl carrier protein. biotin. CDP-choline. phosphatidylglycerol. serine.
2. The diagram to the right shows the change in the structure of the C-terminal portion of each of the ẞ-subu- nits of human hemoglobin (HbA) in the oxyHb to deox- yHb or R-to-T transition. The hydrogen bonding interac- tion of the C-terminal ẞHis 146 residue with the side chain of Asp94, highlighted by the red ellipse, has been shown to be responsible for a major portion of the proton uptake associated with the Bohr effect. Treatment of HbA with the enzyme carboxypeptidase A (CPA) results in loss of the C-terminal ẞHis 146 and ẞTyr145 residues of the ẞ- subunits. (a) ( ) Draw a Hill plot [log(Y/[1-Y]) vs. log(pO2), Y = fraction of heme groups occupied by O2] to compare the values of the Hill coefficient nн and the O2-binding affinity at pH 7.4 of normal HbA before and after treat- ment of with CPA. (b) (' ) How will the plot for CPA-digested HbA change at pH 7.2? (c) 1 Hi5146 HN- ✓ Low PK B-chain. CH2 CH-NH-CO-CH-NH- CH₂ Tyr145 он HbO2 or R state Туг145 CH-CH2- OH co NH CH CH₂ His…
5. Shown below are the first steps in the mechanism of a cysteine protease, which catalyses amide bond hydrolysis in a similar manner as serine proteases. (a) Complete this mechanisms, and (b) sketch the approximate reaction coordinate diagram for this catalyzed reaction relative to the uncatalyzed proteolysis. HN N HN cysteine protease
2. “Most enzymes are gene-encoded proteins." Using this lens, explain: A) effects of increased temperature on the rate of enzymatic reactions, and B) effects of decreased temperature on enzymatic reactions, and C) importance of optimal pH and ionic strength on enzymatic reactions.
2. What is the chemical reaction that lactase catalyzes? Write it below in word form as well as in its chemical equation.
Which of the following steps in glycoylsis is a substrate level phosphorylation? 1,3-BPG --> 3PG GAP --> 1,3-BPG DHAP --> GAP --> Glc-6-P

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