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2. What are the two main mechanisms by which cell signaling is   regulated? What the difference between the two?

2. What are the two main mechanisms by which cell signaling is   regulated? What the difference between the two?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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2. What are the two main mechanisms by which cell signaling is
  regulated? What the difference between the two?

1 Unoccupied receptor does not interact with G, protein. Extra- collular space -Hormone or neuro- transmitter Cell membrane Gs protein with bound GDP Synaptic signaling Receptor Target cell Inactive adenylyl Cytosol GOP cyclase Nerve cell Occupied receptor changes 2 shape and interacts with a subunit of G, protein. G, protein releases GDP and binds GTP. Neurotransmitter Endocrine signaling Hormone Inactive adenylyl cyclase GTP Target cell GDP a Subunit of G, protein 3 dissociates from By and Blood vessel activates adenylyl cyclase. Active adenylyl cyclase Direct contact АТР Gap junction GTP CAMP + PP When hormone is no longer 4 present, the receptor reverts to resting state. GTP on the a subunít is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell Target cells Inactive adenylyl cyclase
Transcribed Image Text:1 Unoccupied receptor does not interact with G, protein. Extra- collular space -Hormone or neuro- transmitter Cell membrane Gs protein with bound GDP Synaptic signaling Receptor Target cell Inactive adenylyl Cytosol GOP cyclase Nerve cell Occupied receptor changes 2 shape and interacts with a subunit of G, protein. G, protein releases GDP and binds GTP. Neurotransmitter Endocrine signaling Hormone Inactive adenylyl cyclase GTP Target cell GDP a Subunit of G, protein 3 dissociates from By and Blood vessel activates adenylyl cyclase. Active adenylyl cyclase Direct contact АТР Gap junction GTP CAMP + PP When hormone is no longer 4 present, the receptor reverts to resting state. GTP on the a subunít is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell Target cells Inactive adenylyl cyclase
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