OH-%OHOHH₂HOHN,OHFigure 1 Structure of TTXNa-OH₂on ChannelMembraneJon ChamelTetrodotoxinFigure 1 Binding of TTX to Sodium channelwww.www.www.wwwwww.www. 2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order thatincludes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by bindingto the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signaltransmission. Propose a computational research project in which you would use TTX as a startingmaterial to design a painkiller (an analgesic drug).Note the following:(50 Marks)You must clearly mention the computational methods/techniques and their significance in thisresearch.Sodium channel Nv1.7 is a transmembrane protein.• TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. Thisis schematically represented in Figure 2.Strong Painkillers partially/ irreversibly block Na channels.

Binding of TTX to Sodium ChannelThe image shows a diagram of the structure of tetrodotoxin (TTX) and…

Answered: OH -% OH OH H₂ HO HN, OH Figure 1…

Chemistry: The Molecular Science

5th Edition

ISBN:9781285199047

Author:John W. Moore, Conrad L. Stanitski

Publisher:John W. Moore, Conrad L. Stanitski

Chapter13: The Chemistry Of Solutes And Solutions

Section: Chapter Questions

Problem 57QRT

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The activity of an enzyme requires a glutamic acid to display its –COOH functional group in the protonated state. Suppose the pKa of the -COOH group is 4.07. What fraction of the enzymes will be active at pH = 4.07? 25% O 75% O 50% 100% 0% Submit Previous Answers Completed Part C At what pH will the enzyme show 80% of maximal activity? Express your answer using two decimal places. ν ΑΣφ pH = Submit Request Answer
to Johnston Commun X Rh Blackboard Collaborate Ultra - x > General Psychology-Fall 2021 A ALEKS - Griffin Barden - Learn + A www-awa.aleks.com/alekscgi/x/Isl.exe/1o_u-IgNslkr7j8P3jH-IJczzdcvSCzsqTCIDqNGV3bKqhMfPmUcQ4ENkmiXn9QCwgeDPDkQ06yszYWESPcekwLO-Qg619rekU7404HgFAGbEZa Dr080?1 oBw7QYjlbavbSPXtx-YCjsh_7mMmrq#item O THERMOCHEMISTRY Griffin Calculating a molar heat of reaction from formation enthalpies Using the table of standard formation enthalpies that you'll find under the ALEKS Data tab, calculate the reaction enthalpy of this reaction under standard conditions: 2C,H;(g)+70,(9)→4 CO,(g)+6H,O() Round your answer to the nearest kJ.
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1. Calculate the Coulombic (ionic) interaction energy between atoms for the C=O ∙∙∙H-N hydrogen bond in a peptide at a distance of 1.5Å in units of kJ/mol. Assume that the partial charge on O is −0.434, the partial charge on H is +0.417 and the permittivity of the protein environment is 6. coulimbic interaction energy= 27.95 kJ/mol 2. The dipole moment of an individual peptide group is approximately 3.46 D. Assuming that the dipoles line up linearly estimate the energy of interaction (in kJ.mol) of the hydrogen bond in Q1 using a dipole-dipole model. *******please answer #2**********
Think of the chemical reactions in which the H⁺ ion is involved. how many positions can this ion bind to lovastatin in the Figure
One common way to determine phosphorus in urine is to treat the sample, after removing the protein, with Mo (VI) and then reducing the resulting 12-molybdophosphate complex with ascorbic acid to give an intense blue colored species called molybdenum blue. The absorbance of molybdenum blue can be measured at 650nm. A 24-hour urine sample was collected and the patient produced 1122mL in 24 hours. A 1.00mL aliquot of the sample was treated with Mo(VI) and ascorbic acid and diluted to a volume of 50.00mL. A calibration curve was prepared by treating 1.00mL aliquots of phosphate standard solutions in the same manner as the urine sample. The absorbances of the standards and the urine sample were obtained at 650nm and the following results obtained: Solution Absorbance at 650nm: 1ppm P0.2302ppm P0.4363ppm P0.6384ppm P0.848Urine sample 0.518 How many grams of phosphorus were eliminated per day by the patient?
professor Scimemi has accepted you as a Master’s student and you are involved in a project that studies the cellular basis of neuropsychiatric diseases. For your electrophysiology recordings you have to make a recording solution containing (in mM): 119 NaCl, 2.5 KCl, 2.5 CaCl2, 1 MgCl2, 26.2 NaHCO3, 1 NaH2PO4, 22 glucose. You need 800 ml of it. How much KCl do you need to weigh out? Hint: we only care about KCl here. (MW KCl is 74.55 g/mol
on O C The u receptors are a class of opioid receptors. The binding affinity of several compounds is shown below: Compound Binding affinity 2.55 nM || ||| IV 33.6 nM 156 nM 600 nM H i. Which compound has the weakest binding to the μ receptor? Justify your answer. ii. Which compound has the strongest binding to the μ receptor? Justify your answer. DJelsim Suppost 2² Tina, me 3 Course Hero' Rewards 2 OSHC Claims (Allian. 7 warded messa N Telsim Prepaid Pack [04933442 invoice and referral - Good morni Good news: you have new rewards o + bly Re-Further information Regi 8 Google recommends Chrome 24℃ 대체로 화창 A 9. 2023
A direct enzyme-linked immunosorbent assay (ELISA) test on a patient's sample is shown below. Development of a strong (dark) color reaction would indicate: 1 Antibody is adsorbed to well. 2 Patient sample is added; complementary antigen binds to antibody. 3 Enzyme-linked antibody specific 4 Enzyme's substrate () is added, for test antigen is added and binds and reaction produces a product that causes a visible color change (O). to antigen, forming sandwich. A low concentration of a specific antigen in the patient's sample O A high concentration of a specific enzyme in the patient's sample The patient's antibody is specific for the enzyme's substrate O A high concentration of a specific antigen in the patient's sample A high concentration of a specific antibody (against the test antigen) in the patient's sample
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15. Modeling ligand binding. A ligand is bound to a protein with a spring-like square-law energy e(x), where x is the distance between the ligand and protein as shown in the figure. e(2) = }ca² Protein Ligand (a) For constant (T,V,N), write an expression for the probability distribution p(x) of the ligand separation from the protein. (b) Sketch a plot of p(x) vs x. Write an expression for the average location of the ligand, (x). (d) Write an expression for the second moment of the location of the ligand, (x2). (e) Calculate the average energy, (e) of the system.
A student is given an antacid tablet that weighed 5.6832g. The tablet was crushed and 4.3628g of the antacid was added to 200 mL of stimulated stomach acid. This was allowed to react and then filtered. It was found that 25 mL of this partially neutralized stomach acid required 8.50 mL of NAOH solution to titrations it to a methyl red endpoint. It took 21.54 mL of this NAOH solution to neutralize 25 mL of the original stomach acid. a)How much of the stomach acid had been neutralized in the 25 mL sample which was titrations? (Show work) B) how much stomach acid was neutralized by the 4.3628 g sample used? (Show work) C)How much stomach acid would have been neutralized by the original 5.6832 g tablet? (Show work)

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