OH-%OHOHH₂HOHN,OHFigure 1 Structure of TTXNa-OH₂on ChannelMembraneJon ChamelTetrodotoxinFigure 1 Binding of TTX to Sodium channelwww.www.www.wwwwww.www. 2. Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order thatincludes pufferfish, porcupinefish, ocean sunfish, and triggerfish. TTX kills its victim by bindingto the victim's voltage-gated sodium channel called Nv1.7, which is crucial for neurological signaltransmission. Propose a computational research project in which you would use TTX as a startingmaterial to design a painkiller (an analgesic drug).Note the following:(50 Marks)You must clearly mention the computational methods/techniques and their significance in thisresearch.Sodium channel Nv1.7 is a transmembrane protein.• TTX is lethal as it irreversibly binds to TTX, which prevents the migration of Na ions. Thisis schematically represented in Figure 2.Strong Painkillers partially/ irreversibly block Na channels.

Binding of TTX to Sodium ChannelThe image shows a diagram of the structure of tetrodotoxin (TTX) and…

Answered: OH -% OH OH H₂ HO HN, OH Figure 1…

Chemistry: The Molecular Science

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ISBN:9781285199047

Author:John W. Moore, Conrad L. Stanitski

Publisher:John W. Moore, Conrad L. Stanitski

Chapter13: The Chemistry Of Solutes And Solutions

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The activity of an enzyme requires a glutamic acid to display its –COOH functional group in the protonated state. Suppose the pKa of the -COOH group is 4.07. What fraction of the enzymes will be active at pH = 4.07? 25% O 75% O 50% 100% 0% Submit Previous Answers Completed Part C At what pH will the enzyme show 80% of maximal activity? Express your answer using two decimal places. ν ΑΣφ pH = Submit Request Answer
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on O C The u receptors are a class of opioid receptors. The binding affinity of several compounds is shown below: Compound Binding affinity 2.55 nM || ||| IV 33.6 nM 156 nM 600 nM H i. Which compound has the weakest binding to the μ receptor? Justify your answer. ii. Which compound has the strongest binding to the μ receptor? Justify your answer. DJelsim Suppost 2² Tina, me 3 Course Hero' Rewards 2 OSHC Claims (Allian. 7 warded messa N Telsim Prepaid Pack [04933442 invoice and referral - Good morni Good news: you have new rewards o + bly Re-Further information Regi 8 Google recommends Chrome 24℃ 대체로 화창 A 9. 2023
3. In patients with early stage lung cancer, stereotactic body radiation therapy (SBRT) has greatly improved survival in patients unable to undergo surgery. In tumors 100 Gy 10 BED have demonstrated significantly improved survival, when compared with doses <100 Gy 10. What is the BED of the following protocol? Would you suggest increasing the dose, or does it appear adequate, assuming the given information? What would you expect as the most likely side effect of therapy for this patient? 3 fractions of 15 Gy delivered every other day.
You are trying to come up with a drug to inhibit the activity of an enzyme thought to have a role in liver disease. In the laboratory the enzyme was shown to have a Km of 1.0 x 10-6 M and Vmax of 0.1 micromoles/min.mg measured at room temperature. You developed an uncompetitive inhibitor. In the presence of 5.0 x 10-5 M inhibitor, the apparent Vmax was determined to be 0.02 micromoles/min.mg. What is the Ki of the inhibitor?
The role of calcium ions (Ca4) in neural signal transmission is to cause the release of neurotransmitter molecules from sodium-potassium pumps in the presynaptic neuron. repolarize the postsynaptic cell after transmission has been completed. increase the activity of the sodium-potassium pumps in the presynaptic cell cause the release of neurotransmitter molecules from synaptic vesicles in the presynaptic neuron.
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This problem can be worked with Equations 18-6 on a calculator or with the spreadsheet in Figure 18-5. Transferrin is the iron-transport protein found in blood. It has a molecular mass of 81 000 and carries two Fe³* ions. Desferrioxamine B is a chelator used to 18-A. treat patients with iron overload (Box 11-1). It has a molecular mass of about 650 and can bind one Fe³+. Desferrioxamine can take iron from many sites within the body and is excreted (with its iron) through the kidneys. Molar absorptivities of these compounds (satu- rated with iron) at two wavelengths are given in the table. Both com- pounds are colorless (no visible absorption) in the absence of iron. e(M¯' cm¯') A(nm) Transferrin Desferrioxamine 428 3 540 2 730 470 4 170 2 290 (a) A solution of transferrin exhibits an absorbance of 0.463 at 470 nm in a 1.000-cm cell. Calculate the concentration of transferrin in mil- ligrams per milliliter and the concentration of bound iron in micro- grams per milliliter. (b) After…
Thank you. I'm just confused as what is is the reason 122.1 has to be multiplied by (-45543.23)?
H J K L Enter V B N M Shift Chapter 2 An Introduction to the Chemistry of Life 37 SELF-QUIZ: TESTING YOUR KNOWLEDGE 1. Each atom has a nucleus made up of р. 24. 2. In atoms, the number of protons is usually equal to the number of 3. The atomic number of an atom is equal to the number of 7. Proteins and carbohydrates consist primarily of carbon, hydrogen, and oxygen; these two molecules are types of and neutrons. -compounds. p. 31. 8. On the pH scale, a pH of is neutral; a solution with a pH less than this is this is 9. Chemicals like bicarbonate that resist pH change are called р. 25. and a solution with a pH greater than р. 32, in the nucleus. p. 26. 4 An alternative form of an atom is called an differs in the number of neutrons in the nucleus. p. 26. 5. A bond formed between two atoms that share electrons is called it p. 33. 10. When water molecules dissociate, they form and ions. p. 32. bond. p. 28. bonds form between oppositely charged atoms of a(n) polar covalent bonds of…
Ac₂0/NaOAc PhCO,H HNO,/H₂SO4 Now

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