2. Based on their effects on enzyme kinetics, identify whether the type of enzyme inhibition by these drugs involves competitive, uncompetitive or noncompetitive inhibition Tamiflu Relenza II. The graph on the right shows the Lineweaver-Burk plots derived from 1/V (umoles/min) 4.5- kinetic data obtained for flu virus +Relenza enzyme activity as substrate concentration in the presence a function of 4 3.5 and absence of two antiviral inhibitor drugs 3 +Tamiflu 2.5 2 No inhibitor И.5 1 -15 -10 -5 0 5 10 15 1/S (HM)

2. Based on their effects on enzyme kinetics, identify whether the type of enzyme inhibition by these drugs involves competitive, uncompetitive or noncompetitive inhibition Tamiflu Relenza II. The graph on the right shows the Lineweaver-Burk plots derived from 1/V (umoles/min) 4.5- kinetic data obtained for flu virus +Relenza enzyme activity as substrate concentration in the presence a function of 4 3.5 and absence of two antiviral inhibitor drugs 3 +Tamiflu 2.5 2 No inhibitor И.5 1 -15 -10 -5 0 5 10 15 1/S (HM)

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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4. Graphing the results from kinetics experiments with enzyme inhibitors The following kinetic data were obtained for an enzyme in the absence of inhibitor (1), and in the presence of two different inhibitors (2) and (3) at 5 mM concentration. Assume [Er] is the same in each experiment. [S] (mM) 1 2 4 8 12 1 2 4 8 12 [S] (mm) a. Determine Vmax and Km for the enzyme. b. Determine the type of inhibition and the Kıfor each inhibitor. 1/[S] M-1 Plot these data as double-reciprocal Lineweaver-Burk plots and use your graph to answers a. and b. 1000 500 250 125 83.3 Answer: The data may be analyzed using double-reciprocal variables. For each [S] and corresponding u, we will calculate 1/[S] and 1/v. sed to get mo Helmien (1) v (μmol/mL sec 12 20 29 35 40 1/v (1) v (1) μmol/mL se mL-sec/umol C 12 20 29 35 40 Please explain how to get K 1/v 20 × 104 10 × 104 -400 8.33x104 5.00x104 3.45x104 2.86x104 2.50x104 Condition No inhibitor 0 5 mM inhibitor (2) 5 mM inhibitor (3) Plots of 1/v vs. 1/[S]…
Please answer C and D.
Please solve this problem
If inhibitor X changes lactase activity to a Vo of 0.10 mM per minute when [S] = 1.0 mM, and a Vo of 0.133333333333 mM per minute when [S] = 2.0 mM, calculate the new Vmax. Calculate the new Km of the above lactase reaction, with inhibitor X. Calculate the slope on a Lineweaver-Burk plot (Km / Vmax) for the lactase reaction with inhibitor X. Inhibitor X exerts which of the following effects on the above enzyme (lactase)?
Find the apparent Km and apparent Vmax for the enzyme reaction containing the inhibitor and identify the type of inhibitor The increment on the X axis is 25uM The increment on the Y axis is 8 sec uM We VISI O appvmax-0.05microM/sec; appKm=0.02microM: mixed O appvmax-0.05microM/sec; appKm=0.02microM; uncompetitive O appvmax-0.075microM/sec, appKm-0.013microM; competitive O appvmax-0.05microM/sec; appKm-0.013microM; uncompetitive O appvmax 75microM/sec; appKm-13.3microM; uncompetitive
Calculate the slope on a Lineweaver-Burk plot (Km / Vmax) for the lactase reaction with inhibitor X. (inhibitor X changes lactase activity to a Vo of 0.10 mM per minute when [S] = 1.0 mM, and a Vo of 0.133333333333 mM per minute when [S] = 2.0 mM) 0.20 per minute 0.50 per minute 1.0 per minute 2.0 per minute 5.0 per minute
Solve the given problem related to population growth. The number of bacteria N(t) present in a culture at time t hours is given by N(t) = 2000(2). Find the number of bacteria when t = 0 hours and t = 5 hours. (a) t = 0 hours (b) bacteria t = 5 hours bacteria