2. Aspirin can be absorbed into the blood through the cells lining the stomach and the small intestine. a. The pH inside the stomach is ~ 2.0 and the pH inside the small intestine is ~ 6.0. The stomach has times higher [H*] than the small intestine. b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when it is in the stomach or in the small intestine: Stomach (pH = 2.0): Overall Charge: Small Intestine (pH= 6.0): Overall Charge: c. Drug absorption requires passage through the hydrophobic plasma membrane, the rate of which is determined by the polarity of the drug molecule: charged and extremely polar molecules pass slowly, whereas neutral and hydrophobic ones pass rapidly. Based on your answer in #2b, explain why aspirin is more likely to be absorbed into the bloodstream via the stomach than the small intestine.
2. Aspirin can be absorbed into the blood through the cells lining the stomach and the small intestine. a. The pH inside the stomach is ~ 2.0 and the pH inside the small intestine is ~ 6.0. The stomach has times higher [H*] than the small intestine. b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when it is in the stomach or in the small intestine: Stomach (pH = 2.0): Overall Charge: Small Intestine (pH= 6.0): Overall Charge: c. Drug absorption requires passage through the hydrophobic plasma membrane, the rate of which is determined by the polarity of the drug molecule: charged and extremely polar molecules pass slowly, whereas neutral and hydrophobic ones pass rapidly. Based on your answer in #2b, explain why aspirin is more likely to be absorbed into the bloodstream via the stomach than the small intestine.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
![2. Aspirin can be absorbed into the blood through the cells lining the stomach and the small intestine.
a. The pH inside the stomach is ~ 2.0 and the pH inside the small intestine is ~ 6.0. The stomach has
times higher [H*] than the small intestine.
b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1)
when it is in the stomach or in the small intestine:
Stomach (pH=2.0):
Overall Charge:
Small Intestine (pH= 6.0):
Overall Charge:
c. Drug absorption requires passage through the hydrophobic plasma membrane, the rate of which is
determined by the polarity of the drug molecule: charged and extremely polar molecules pass slowly,
whereas neutral and hydrophobic ones pass rapidly. Based on your answer in #2b, explain why aspirin
is more likely to be absorbed into the bloodstream via the stomach than the small intestine.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F0901a950-03a3-432e-9552-ea2a92b8bfcf%2F3976b18e-9fe3-4dda-b4eb-bbe6b0700818%2Fbx3gpv_processed.png&w=3840&q=75)
Transcribed Image Text:2. Aspirin can be absorbed into the blood through the cells lining the stomach and the small intestine.
a. The pH inside the stomach is ~ 2.0 and the pH inside the small intestine is ~ 6.0. The stomach has
times higher [H*] than the small intestine.
b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1)
when it is in the stomach or in the small intestine:
Stomach (pH=2.0):
Overall Charge:
Small Intestine (pH= 6.0):
Overall Charge:
c. Drug absorption requires passage through the hydrophobic plasma membrane, the rate of which is
determined by the polarity of the drug molecule: charged and extremely polar molecules pass slowly,
whereas neutral and hydrophobic ones pass rapidly. Based on your answer in #2b, explain why aspirin
is more likely to be absorbed into the bloodstream via the stomach than the small intestine.
Expert Solution

This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 4 steps with 1 images

Recommended textbooks for you

Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman

Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY

Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman

Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY

Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning

Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning

Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON