2. Aspirin can be absorbed into the blood through the cells lining the stomach and the small intestine. a. The pH inside the stomach is ~ 2.0 and the pH inside the small intestine is ~ 6.0. The stomach has times higher [H*] than the small intestine. b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when it is in the stomach or in the small intestine: Stomach (pH = 2.0): Overall Charge: Small Intestine (pH= 6.0): Overall Charge: c. Drug absorption requires passage through the hydrophobic plasma membrane, the rate of which is determined by the polarity of the drug molecule: charged and extremely polar molecules pass slowly, whereas neutral and hydrophobic ones pass rapidly. Based on your answer in #2b, explain why aspirin is more likely to be absorbed into the bloodstream via the stomach than the small intestine.
2. Aspirin can be absorbed into the blood through the cells lining the stomach and the small intestine. a. The pH inside the stomach is ~ 2.0 and the pH inside the small intestine is ~ 6.0. The stomach has times higher [H*] than the small intestine. b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when it is in the stomach or in the small intestine: Stomach (pH = 2.0): Overall Charge: Small Intestine (pH= 6.0): Overall Charge: c. Drug absorption requires passage through the hydrophobic plasma membrane, the rate of which is determined by the polarity of the drug molecule: charged and extremely polar molecules pass slowly, whereas neutral and hydrophobic ones pass rapidly. Based on your answer in #2b, explain why aspirin is more likely to be absorbed into the bloodstream via the stomach than the small intestine.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
![2. Aspirin can be absorbed into the blood through the cells lining the stomach and the small intestine.
a. The pH inside the stomach is ~ 2.0 and the pH inside the small intestine is ~ 6.0. The stomach has
times higher [H*] than the small intestine.
b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1)
when it is in the stomach or in the small intestine:
Stomach (pH=2.0):
Overall Charge:
Small Intestine (pH= 6.0):
Overall Charge:
c. Drug absorption requires passage through the hydrophobic plasma membrane, the rate of which is
determined by the polarity of the drug molecule: charged and extremely polar molecules pass slowly,
whereas neutral and hydrophobic ones pass rapidly. Based on your answer in #2b, explain why aspirin
is more likely to be absorbed into the bloodstream via the stomach than the small intestine.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F0901a950-03a3-432e-9552-ea2a92b8bfcf%2F3976b18e-9fe3-4dda-b4eb-bbe6b0700818%2Fbx3gpv_processed.png&w=3840&q=75)
Transcribed Image Text:2. Aspirin can be absorbed into the blood through the cells lining the stomach and the small intestine.
a. The pH inside the stomach is ~ 2.0 and the pH inside the small intestine is ~ 6.0. The stomach has
times higher [H*] than the small intestine.
b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1)
when it is in the stomach or in the small intestine:
Stomach (pH=2.0):
Overall Charge:
Small Intestine (pH= 6.0):
Overall Charge:
c. Drug absorption requires passage through the hydrophobic plasma membrane, the rate of which is
determined by the polarity of the drug molecule: charged and extremely polar molecules pass slowly,
whereas neutral and hydrophobic ones pass rapidly. Based on your answer in #2b, explain why aspirin
is more likely to be absorbed into the bloodstream via the stomach than the small intestine.
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