18. The figure below shows how various factors affect the oxygen equilibrium curve. During exercise, which of the factors change(s) in the muscle tissue? How that change(s) affect respiratory function? Hemoglobin saturation (%) 100 PCO2 80 ↓ 2,3-DPG ↑ pH 60 40 20 0 Decreased P50 (increased affinity) Temperature 0 Increased P50 (decreased affinity) 20 ↑ Temperature ↑ PCO₂ 12,3-DPG pH 40 60 80 Oxygen partial pressure (mm Hg) Koeppen & Stanton: Berne and Levy Physiology, 6th Edition. Copyright 2008 by Mosby, an imprint of Elsevier, Inc. All rights reserved 100

Basic Clinical Lab Competencies for Respiratory Care: An Integrated Approach
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Author:White
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Chapter26: Advanced Modes Of Mechanical Ventilation
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18. The figure below shows how various factors affect the oxygen
equilibrium curve. During exercise, which of the factors
change(s) in the muscle tissue? How that change(s) affect
respiratory function?
Hemoglobin saturation (%)
100
PC02
80 ↓ 2,3-DPG
↑ pH
60
40
20
0
Decreased P50 (increased affinity)
Temperature
0
Increased P50
(decreased affinity)
20
↑ Temperature
↑ PC02
↑ 2,3-DPG
pH
40
60
80
Oxygen partial pressure (mm Hg)
Koeppen & Stanton: Berne and Levy Physiology, 6th Edition.
Copyright 2008 by Mosby, an imprint of Elsevier, Inc. All rights reserved
100
Transcribed Image Text:18. The figure below shows how various factors affect the oxygen equilibrium curve. During exercise, which of the factors change(s) in the muscle tissue? How that change(s) affect respiratory function? Hemoglobin saturation (%) 100 PC02 80 ↓ 2,3-DPG ↑ pH 60 40 20 0 Decreased P50 (increased affinity) Temperature 0 Increased P50 (decreased affinity) 20 ↑ Temperature ↑ PC02 ↑ 2,3-DPG pH 40 60 80 Oxygen partial pressure (mm Hg) Koeppen & Stanton: Berne and Levy Physiology, 6th Edition. Copyright 2008 by Mosby, an imprint of Elsevier, Inc. All rights reserved 100
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