Please answer all parts if possible 7.In a study conducted some years ago, cats werefasted overnight then given a single meal complete inall amino acids except arginine. Within 2 hours, bloodammonia levels increased from a normal level of18ug/L to 140µg/L, and the cats showed the clinicalsymptoms of ammonia toxicity. A control group fed acomplete amino acid diet or an amino acid diet inwhich arginine was replaced by ornithine showed nounusual clinical symptoms.(a) What was the role of fasting in the experiment?(b) What caused the ammonia levels to rise in theexperimental group? Why did the absence of argininelead to ammonia toxicity? Is arginine an essentialamino acid in cats? Why or why not?(c) Why can ornithine be substituted for arginine?

Urea Cycle The urea cycle is the first cyclic metabolic pathway to be discovered. In the body,…

In a study conducted some years ago, cats were sted overnight then given a single meal complete in I amino acids except arginine. Within 2 hours, blood mmonia levels increased from a normal level of Bug/L to 140µg/L, and the cats showed the clinionl

In a study conducted some years ago, cats were sted overnight then given a single meal complete in I amino acids except arginine. Within 2 hours, blood mmonia levels increased from a normal level of Bug/L to 140µg/L, and the cats showed the clinionl

Basic Clinical Laboratory Techniques 6E

6th Edition

ISBN:9781133893943

Author:ESTRIDGE

Publisher:ESTRIDGE

Chapter6: Basic Clinical Chemistry

Section6.1: Introduction To Clinical Chemistry

Problem 14RQ

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Question

Please answer all parts if possible

7.In a study conducted some years ago, cats were
fasted overnight then given a single meal complete in
all amino acids except arginine. Within 2 hours, blood
ammonia levels increased from a normal level of
18ug/L to 140µg/L, and the cats showed the clinical
symptoms of ammonia toxicity. A control group fed a
complete amino acid diet or an amino acid diet in
which arginine was replaced by ornithine showed no
unusual clinical symptoms.
(a) What was the role of fasting in the experiment?
(b) What caused the ammonia levels to rise in the
experimental group? Why did the absence of arginine
lead to ammonia toxicity? Is arginine an essential
amino acid in cats? Why or why not?
(c) Why can ornithine be substituted for arginine?

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