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What is he physiological significance for Km?

What is he physiological significance for Km?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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2) What is he physiological significance for Km? 3) After such a large meal, which of the following scenarios describes the relative activity levels for these two enzyme? Please explain the reason for your choice. Hexokinase Glucokinase A. Not active Not active B. v = 1/2Vmax Not active C. v Vmax Not active D. v Vmax v= 1/½Vmax E. v = Vmax v= Vmax
Transcribed Image Text:2) What is he physiological significance for Km? 3) After such a large meal, which of the following scenarios describes the relative activity levels for these two enzyme? Please explain the reason for your choice. Hexokinase Glucokinase A. Not active Not active B. v = 1/2Vmax Not active C. v Vmax Not active D. v Vmax v= 1/½Vmax E. v = Vmax v= Vmax
5.Glucose taken up by liver cells is rapidly phosphorylated to glucose 6-phosphate with ATP serving as the phosphate donor in the initial step of metabolism and assimilation of the sugar. Two enzymes, which may be considered isozymes, are capable of catalyzing this reaction in the liver cell. Hexokinase has a low Km of ~0.05 mM for glucose, whereas glucokinase exhibits sigmoidal kinetics with an approximate Km of ~5 mM. After a large meal, the glucose concentration in the hepatic portal vein may approximate 5 mM. 1) Please describe the possible catabolic pathways for glucose in our bodies. 2) What is the physiological significance for Km?
Transcribed Image Text:5.Glucose taken up by liver cells is rapidly phosphorylated to glucose 6-phosphate with ATP serving as the phosphate donor in the initial step of metabolism and assimilation of the sugar. Two enzymes, which may be considered isozymes, are capable of catalyzing this reaction in the liver cell. Hexokinase has a low Km of ~0.05 mM for glucose, whereas glucokinase exhibits sigmoidal kinetics with an approximate Km of ~5 mM. After a large meal, the glucose concentration in the hepatic portal vein may approximate 5 mM. 1) Please describe the possible catabolic pathways for glucose in our bodies. 2) What is the physiological significance for Km?
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