10. A scientist working in a research laboratory has been examining different agonists of serotonin receptor 1B (5-HT1B), a G-protein-coupled re- ceptor. Compound A has a much higher affin- ity for 5-HT1B than compound B. Both com- pounds have a higher affinity for the receptor than serotonin. Which of the following de- scribes the relationship between compound A and compound B when considering the guan- ine-nucleotide exchange activity of 5-HT1B? (A) Km for the exchange reaction with com- pound A is higher than that with com- pound B (B) Km for the exchange reaction with com- pound A is lower than that with compound в (C) Km values with compounds A and B are the same (D) The maximum reaction rate with com- pound A is greater than that with com- pound B (E) The maximum reaction rate with com- pound B is greater than that with com- pound A|

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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10. A scientist working in a research laboratory has
been examining different agonists of serotonin
receptor 1B (5-HT1B), a G-protein-coupled re-
ceptor. Compound A has a much higher affin-
ity for 5-HT1B than compound B. Both com-
pounds have a higher affinity for the receptor
than serotonin. Which of the following de-
scribes the relationship between compound A
and compound B when considering the guan-
ine-nucleotide exchange activity of 5-HT1B?
(A) Km for the exchange reaction with com-
pound A is higher than that with com-
pound B
(B) Km for the exchange reaction with com-
pound A is lower than that with compound
B
(C) Km values with compounds A and B are
the same
(D) The maximum reaction rate with com-
pound A is greater than that with com-
pound B
(E) The maximum reaction rate with com-
pound B is greater than that with com-
pound A
Transcribed Image Text:10. A scientist working in a research laboratory has been examining different agonists of serotonin receptor 1B (5-HT1B), a G-protein-coupled re- ceptor. Compound A has a much higher affin- ity for 5-HT1B than compound B. Both com- pounds have a higher affinity for the receptor than serotonin. Which of the following de- scribes the relationship between compound A and compound B when considering the guan- ine-nucleotide exchange activity of 5-HT1B? (A) Km for the exchange reaction with com- pound A is higher than that with com- pound B (B) Km for the exchange reaction with com- pound A is lower than that with compound B (C) Km values with compounds A and B are the same (D) The maximum reaction rate with com- pound A is greater than that with com- pound B (E) The maximum reaction rate with com- pound B is greater than that with com- pound A
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