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10. A racemic mixture of (R)- and (S)- citalopram (figure 4) needs to be separated by liquid chromatography and detected. The separation is achieved with reversed phase chromatography. Figure 4 F F H3C N-CH3 -CH3 H3C Answer ALL parts of this question. a) Discuss whether the enantiomers in Figure 4 are fluorescent and if so whether fluorescence can help to differentiate them. b) Discuss whether the enantiomers in Figure 4 will have a signal in Raman spectroscopy, and if so, whether the Raman spectra can help to differentiate them. c) Describe the experimental conditions that would be needed to attempt their separation with ion pair chromatography. d) Propose an alternative technique to ion pair chromatography for the fast separation of both molecules in Figure 4.

10. A racemic mixture of (R)- and (S)- citalopram (figure 4) needs to be separated by liquid chromatography and detected. The separation is achieved with reversed phase chromatography. Figure 4 F F H3C N-CH3 -CH3 H3C Answer ALL parts of this question. a) Discuss whether the enantiomers in Figure 4 are fluorescent and if so whether fluorescence can help to differentiate them. b) Discuss whether the enantiomers in Figure 4 will have a signal in Raman spectroscopy, and if so, whether the Raman spectra can help to differentiate them. c) Describe the experimental conditions that would be needed to attempt their separation with ion pair chromatography. d) Propose an alternative technique to ion pair chromatography for the fast separation of both molecules in Figure 4.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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10. A racemic mixture of (R)- and (S)- citalopram (figure 4) needs to be separated by liquid chromatography and detected. The separation is achieved with reversed phase chromatography. Figure 4 F F H3C N-CH3 -CH3 H3C Answer ALL parts of this question. a) Discuss whether the enantiomers in Figure 4 are fluorescent and if so whether fluorescence can help to differentiate them. b) Discuss whether the enantiomers in Figure 4 will have a signal in Raman spectroscopy, and if so, whether the Raman spectra can help to differentiate them. c) Describe the experimental conditions that would be needed to attempt their separation with ion pair chromatography. d) Propose an alternative technique to ion pair chromatography for the fast separation of both molecules in Figure 4.
Transcribed Image Text:10. A racemic mixture of (R)- and (S)- citalopram (figure 4) needs to be separated by liquid chromatography and detected. The separation is achieved with reversed phase chromatography. Figure 4 F F H3C N-CH3 -CH3 H3C Answer ALL parts of this question. a) Discuss whether the enantiomers in Figure 4 are fluorescent and if so whether fluorescence can help to differentiate them. b) Discuss whether the enantiomers in Figure 4 will have a signal in Raman spectroscopy, and if so, whether the Raman spectra can help to differentiate them. c) Describe the experimental conditions that would be needed to attempt their separation with ion pair chromatography. d) Propose an alternative technique to ion pair chromatography for the fast separation of both molecules in Figure 4.
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