1. The following reactions can be coupled in the citrate cycle. Succinyl-CoA GDP + Pi. succinate + CoA GTP AGO'= -34.0 kJ/mo AGO= 30.5 kJ/mol a) Write the net reaction. Calculate AGº for the coupled reaction. Is the reaction favorable? b) Write the equilibrium constant in terms of reactant and product concentration. Calculate the equilibrium constant, K, for the coupled reaction at 37°C. c) If the ratio of [GTP/[GDP] in the cell is 22, the [CoA]/[succinyl-CoA] ratio is 0.20, and the [Pi] is 1.3mM, determine the [Succinate] at equilibrium. (Pay attention to concentration units) d) If the [GTP/[GDP] falls to 4.0, calculate AG', keeping all other concentrations the same. If the [GTP/[GDP] increases to 75, calculate AG', keeping all other concentrations the same.
1. The following reactions can be coupled in the citrate cycle. Succinyl-CoA GDP + Pi. succinate + CoA GTP AGO'= -34.0 kJ/mo AGO= 30.5 kJ/mol a) Write the net reaction. Calculate AGº for the coupled reaction. Is the reaction favorable? b) Write the equilibrium constant in terms of reactant and product concentration. Calculate the equilibrium constant, K, for the coupled reaction at 37°C. c) If the ratio of [GTP/[GDP] in the cell is 22, the [CoA]/[succinyl-CoA] ratio is 0.20, and the [Pi] is 1.3mM, determine the [Succinate] at equilibrium. (Pay attention to concentration units) d) If the [GTP/[GDP] falls to 4.0, calculate AG', keeping all other concentrations the same. If the [GTP/[GDP] increases to 75, calculate AG', keeping all other concentrations the same.
Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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![1. The following reactions can be coupled in the citrate cycle.
\[ \text{Succinyl-CoA} \rightleftharpoons \text{succinate + CoA} \]
\[ \text{GDP + Pi} \rightleftharpoons \text{GTP} \]
\[
\Delta G^{o'} = -34.0 \, \text{kJ/mol} \quad
\Delta G^{o'} = 30.5 \, \text{kJ/mol}
\]
a) Write the net reaction. Calculate \(\Delta G^{o'}\) for the coupled reaction. Is the reaction favorable?
b) Write the equilibrium constant in terms of reactant and product concentration. Calculate the equilibrium constant, K, for the coupled reaction at 37°C.
c) If the ratio of [GTP]/[GDP] in the cell is 22, the [CoA]/[succinyl-CoA] ratio is 0.20, and the [Pi] is 1.3 mM, determine the [Succinate] at equilibrium. (Pay attention to concentration units)
d) If the [GTP]/[GDP] falls to 4.0, calculate \(\Delta G'\), keeping all other concentrations the same. If the [GTP]/[GDP] increases to 75, calculate \(\Delta G'\), keeping all other concentrations the same.
e) What conclusion can you reach about the direction of the reaction under these cellular conditions? Is this reaction reversible or irreversible?](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fda3085ce-1e06-4366-ab49-1fc5094c490f%2F014305a9-8c41-4c0a-87c5-4103702e6ced%2Frpjnvr_processed.png&w=3840&q=75)
Transcribed Image Text:1. The following reactions can be coupled in the citrate cycle.
\[ \text{Succinyl-CoA} \rightleftharpoons \text{succinate + CoA} \]
\[ \text{GDP + Pi} \rightleftharpoons \text{GTP} \]
\[
\Delta G^{o'} = -34.0 \, \text{kJ/mol} \quad
\Delta G^{o'} = 30.5 \, \text{kJ/mol}
\]
a) Write the net reaction. Calculate \(\Delta G^{o'}\) for the coupled reaction. Is the reaction favorable?
b) Write the equilibrium constant in terms of reactant and product concentration. Calculate the equilibrium constant, K, for the coupled reaction at 37°C.
c) If the ratio of [GTP]/[GDP] in the cell is 22, the [CoA]/[succinyl-CoA] ratio is 0.20, and the [Pi] is 1.3 mM, determine the [Succinate] at equilibrium. (Pay attention to concentration units)
d) If the [GTP]/[GDP] falls to 4.0, calculate \(\Delta G'\), keeping all other concentrations the same. If the [GTP]/[GDP] increases to 75, calculate \(\Delta G'\), keeping all other concentrations the same.
e) What conclusion can you reach about the direction of the reaction under these cellular conditions? Is this reaction reversible or irreversible?
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So, the reaction would be irreversible and from left to right under cellular conditions?
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