. 2 3 1 4 . 56 I 7. ..(a) Identify the point in mitosis at which separase cleaves the protein complex that holds sister chromatid pairs together. Innormal cells, separase is kept in an inactive state until it is needed. Explain how the progression of cells past sequential cellcycle checkpoints and the activity of enzymes such as separase is controlled by interactions between two major groups ofregulatory proteins.(b) Identify an independent variable in the experiment graphed in Figure 1. Based on the data in Figure 1, identify a controlthat shows that Sepin-1 rather than something else in the culture medium is inhibiting the growth of the cancer cells.(c) Based on the data in Table 1, describe the general relationship between the sensitivity of cells to Sepin-1 and theconcentration of separase in the cells. Use the Figure 1 data to calculate the ratio between the amount of Sepin-1 requiredto kill 50% of the cells in the cell line that is most sensitive to the compound and the cell line that is least sensitive to thecompound.(d) The scientists hope to test Sepin-1 in clinical trials with human cancer patients. The scientists claim that one way to testthe efficacy of the Sepin-1 treatment will be to obtain periodic samples of the patients' cancer cells and determine thepercent of cells in metaphase. Provide reasoning to support the scientists' claim.US

Name: . 2 3 1 4 . 56 I 7. ..(a) Identify the point in mitosis at which sepa
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Description: . 2 3 1 4 . 56 I 7. ..(a) Identify the point in mitosis at which separase cleaves the protein complex that holds sister chromatid pairs together. Innormal cells, separase is kept in an inactive state until it is needed. Explain how the progression o