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. Neurobiology of speech and language has been studied in a family in which half of the members have severe impairment in both speech and language. The mutation responsible for the phenotype was identified in the FOXP2 gene. In addition, this gene is found on a chromosome segment tightly linked to autism, a disorder in which language is impaired. How would you directly test the hypothesis that this gene is necessary for vocal communication in other mammals? a. Use molecular genetic techniques to disrupt (inactivate) the mouse Foxp2 gene and observe the effect on ultrasonic vocalizations in the knockout mice. b. Determine the DNA sequence of the FOXP2 gene in several species of mammals that communicate vocally and compare these sequences to the DNA sequence for the human gene to determine whether the gene is evolutionarily conserved. c. Compare neural expression patterns of the FOXP2 gene between species that communicate vocally and related species that do not communicate vocally to determine whether there are consistent differences between these groups. d. Use transgenics to introduce the FOXP2 gene from a species that is vocal into a related species that is not vocal and observe the effect on phenotype. e. Characterize expression of the FOXP2 gene during development to determine whether expression of the gene begins at the same time as a species is acquiring its ability to Yocalize.

. Neurobiology of speech and language has been studied in a family in which half of the members have severe impairment in both speech and language. The mutation responsible for the phenotype was identified in the FOXP2 gene. In addition, this gene is found on a chromosome segment tightly linked to autism, a disorder in which language is impaired. How would you directly test the hypothesis that this gene is necessary for vocal communication in other mammals? a. Use molecular genetic techniques to disrupt (inactivate) the mouse Foxp2 gene and observe the effect on ultrasonic vocalizations in the knockout mice. b. Determine the DNA sequence of the FOXP2 gene in several species of mammals that communicate vocally and compare these sequences to the DNA sequence for the human gene to determine whether the gene is evolutionarily conserved. c. Compare neural expression patterns of the FOXP2 gene between species that communicate vocally and related species that do not communicate vocally to determine whether there are consistent differences between these groups. d. Use transgenics to introduce the FOXP2 gene from a species that is vocal into a related species that is not vocal and observe the effect on phenotype. e. Characterize expression of the FOXP2 gene during development to determine whether expression of the gene begins at the same time as a species is acquiring its ability to Yocalize.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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84. Neurobiology of speech and language has been studied in a family in which half of the members have severe impairment in both speech and language. The mutation responsible for the phenotype was identified in the FOXP2 gene. In addition, this gene is found on a chromosome segment tightly linked to autism, a disorder in which language is impaired. How would you directly test the hypothesis that this gene is necessary for vocal communication in other mammals? a. Use molecular genetic techniques to disrupt (inactivate) the mouse Foxp2 gene and observe the effect on ultrasonic vocalizations in the knockout mice. b. Determine the DNA sequence of the FOXP2 gene in several species of mammals that communicate vocally and compare these sequences to the DNA sequence for the human gene to determine whether the gene is evolutionarily conserved. c. Compare neural expression patterns of the FOXP2 gene between species that communicate vocally and related species that do not communicate vocally to determine whether there are consistent differences between these groups. d. Use transgenics to introduce the FOXP2 gene from a species that is vocal into a related species that is not vocal and observe the effect on phenotype. e. Characterize expression of the FOXP2 gene during development to determine whether expression of the gene begins at the same time as a species is acquiring its ability to vocalize.
Transcribed Image Text:84. Neurobiology of speech and language has been studied in a family in which half of the members have severe impairment in both speech and language. The mutation responsible for the phenotype was identified in the FOXP2 gene. In addition, this gene is found on a chromosome segment tightly linked to autism, a disorder in which language is impaired. How would you directly test the hypothesis that this gene is necessary for vocal communication in other mammals? a. Use molecular genetic techniques to disrupt (inactivate) the mouse Foxp2 gene and observe the effect on ultrasonic vocalizations in the knockout mice. b. Determine the DNA sequence of the FOXP2 gene in several species of mammals that communicate vocally and compare these sequences to the DNA sequence for the human gene to determine whether the gene is evolutionarily conserved. c. Compare neural expression patterns of the FOXP2 gene between species that communicate vocally and related species that do not communicate vocally to determine whether there are consistent differences between these groups. d. Use transgenics to introduce the FOXP2 gene from a species that is vocal into a related species that is not vocal and observe the effect on phenotype. e. Characterize expression of the FOXP2 gene during development to determine whether expression of the gene begins at the same time as a species is acquiring its ability to vocalize.
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