. Geneticists interested in human hemoglobins havefound a very large number of mutant forms. Some ofthese mutant proteins are of normal size (but haveamino acid substitutions) while others are short, dueto deletions or nonsense mutations. The first extralong example was named Hb Constant Spring, inwhich the β-globin has all of its normal amino acidsplus several extra amino acids attached after thenormal C-terminal end of the protein. a. What is the most plausible explanation forits origin?b. Is it possible that Hb Constant Spring arose fromfailure to splice out an intron?c. Estimate how many extra amino acids mightbe added to the C terminal end of the mutantprotein

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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. Geneticists interested in human hemoglobins have
found a very large number of mutant forms. Some ofthese mutant proteins are of normal size (but have
amino acid substitutions) while others are short, due
to deletions or nonsense mutations. The first extralong example was named Hb Constant Spring, in
which the β-globin has all of its normal amino acids
plus several extra amino acids attached after the
normal C-terminal end of the protein.
a. What is the most plausible explanation for
its origin?
b. Is it possible that Hb Constant Spring arose from
failure to splice out an intron?
c. Estimate how many extra amino acids might
be added to the C terminal end of the mutant
protein

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