Pre lab 8

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University at Buffalo *

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113

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Chemistry

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Jan 9, 2024

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University at Buffalo Organic Chemistry Lab CHE 205 & 251 Fall 2023 Dr. K. Ahsan Take home Pre-lab Procedure # 8 (Lab 8): SN1 Reaction (3 points)- Complete and upload as “Pre-Lab Assignment -Synthesis of Alkyl Halides - To Download” on Labflow. Before your recitation start time Name: TA: Lab Day & time: Answer the following questions on this sheet using words, chemical structures and reaction equations as required. 1) Using chemical structures draw the complete chemical reaction mechanism of the reaction of 2 methyl 2 butanol with HCl, provide all the products and any intermediates involved (1.0 point)
2) For reaction drawn above, what is the theoretical yield if you started with 1.5 mL of 2 methyl 2 butanol (MW = 88.15 g/mol; density = 0.805 g/mL) and excess HCl to produce the product (MW= 106.59.15 g/mol)? . 1.0 point Theoretical yield = (1.5/0.805) x 106.59 = 198.61 g
3) Using your own words, provide the procedure for the synthesis of 2-chloro-2-methylbutane via an SN1 Reaction. 1.0 point In the synthesis of 2-chloro-2-methylbutane through an SN1 reaction, 1.5 mL of 2-methyl-2- butanol is mixed with 2.5 mL of concentrated 12M hydrochloric acid in a conical vial equipped with a magnetic spin vane. After stirring for 10-15 minutes, the reaction mixture is transferred to a centrifuge tube, and the organic layer is extracted with diethyl ether. The resulting solution is treated with saturated sodium bicarbonate, and the layers are separated. The organic layer is then dried with anhydrous sodium sulfate, and the solvent is evaporated. The mass of the product is obtained, and its identity is confirmed by a silver nitrate test, which results in the formation of a white precipitate. Safety precautions include the use of protective gear and working in a fume hood due to the corrosive nature of hydrochloric acid and chlorinated hydrocarbons. Cleanup involves proper disposal of waste and cleaning the work area.
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