CASE+STUDY+2_

What are the differences between Ligand based and Receptor based pharmacophores?

This pre-analytical variable can have an effect on chemistry tests which are read visually by spectrophotometry:   Question 8 options:   all answers are correct   icterus   lipemia   hemolysis

Case Studies An 18-year-old male high school student who had a 4-year history of diabetes mellitus was brought to the emergency department because of excessive drowsiness, vomiting. and diarrhea. His diabetes had been well controlled with 40 units of NPH insulin daily until several days ago when he developed excessive thirst and polyuria. For the past 3 days, he has also had headaches, myalgia, and a low-grade fever. Diarrhea and vomiting began 1 day ago Chemistry Test Results Sodium 126 mmol/L Urinalysis Results Specific 1.012 gravity pH 5.0 Glucose 4+ Ketone Large Potassium Chloride Bicarbonate Plasma glucose 6.1 mmol/L 87 mmol/L 6 mmol/L 600 mg/dL BUN Creatinine Serum ketones 48 mg/dL. 2.0 mg/dL 4+ 1. What is the probable diagnosis of this patient 2. What laboratory test(s) should be performed to follow this patient and aid in adjusting insulin levels? 3. Why are the urine ketones positive? 4. What methods are used to quantitate urine ketones? Which ketone(s) do they detect?

1.      A 75-year-old man is given an infusion of lidocaine for the control of ventricular tachycardia. A dose adjustment is required. Which of the following parameters would be the most important in selecting a new infusion rate that is therapeutically effective but non-toxic?   A.    Bioavailability B.     Clearance C.     Glomerular filtration rate D.    Volume of distribution       1.      A 15-year-old girl has severe cramping pain that begins a few hours before the start of her menstrual flow. She says that the pain has occurred monthly for the past 9 months. She also complains of headache and of being very tired during the menstrual period. Which of the following is the most appropriate therapy?   A.    Acetaminophen B.     Celecoxib C.     Dexamethasone   D.    Ibuprofen

Calculate creatinine clearance from the following results.urine creatinine=75 mg/dLurine volume=850 mL/24 hoursserum creatinine=0.9 mg/dLbody surface area=1.55 m2     Question 32 options:   A)  44.1 mL/min   B)  >60 mL/min   C)  3.3 mL/min   D)  54.9 mL/min

Viagra inhibit PDE5？what does it means？what will happen if Viagra inhibit PDE5？

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Medication associated with cumulative doses resulting in delayed myelotoxicity carmustine Ifosfamide methotrexate Oxaliplatin

a) Lysine is an essential amino acid. It is taken by some people as a nutritional supplement in the form of a hydrated crystalline solid with the formula C6H₁4N2O2.XH₂O . To control the dose of lysine, it is essential to know the complete formula of the hydrate, which means determining the value of x. To determine the value of x in lysine hydrate, a pharmacist used a direct titration method. She dissolved 6.258g of the compound in approximately 100mL of distilled water and then made this up to 250mL in a volumetric flask. She then titrated 25mL aliquots of this solution with a standardized NaOH solution of concentration 0.1050 mol dm-³, obtaining a mean titre of 36.30 mL. In titrations, lysine behaves as a monoprotic acid. Use these data to determine the value of x in lysine hydrate. b) In a second experiment to verify the value of x, the pharmacist heated a 3.752g sample of the lysine hydrate to drive off all the water. When she reweighed the sample, the mass was 3.278 g. Use this…

2. Compare the following two protocols used to treat oral squamous cell carcinoma in cats. Which would have more severe acute effects? Which is more likely to have severe late effects? Which would have a better likelihood of tumor control? 63 Gy delivered in 21 equal fractions; 49 Gy delivered in 14 equal fractions