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Feb 20, 2024

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Erline Constant Hydroxide and its Benefits in Reducing Acid Introduction: Many individuals suffer from acid reflux or issues like indigestion. An antacid can allow them relief from this. An antacid is a medicine that can neutralize the acid in one’s stomach (2). There are many different brands of antacids such as Tums Ultra, Gaviscon, and Mylanta. But this raises the question, which is the most effective? When posing the question of which antacid is the most effective at neutralizing the most acid, there’s a multitude of different factors that can play into this, such as active ingredients, as well as general price. While there are many different active ingredients such as aluminum hydroxide and magnesium hydroxide, I predict that the active ingredient of carbonate is the most important factor when determining how much acid an an tacid can neutralize. “Calcium Carbonate [CaCO3] Calcium Carbonate (chalk) is the most potent usable antacid” (1). It can completely neutralize the acid in the stomach and turn it into water. Out of the antacids we’re testing, I predict that Tums Ultra with 2,000 mg of carbonate per dose and Mylanta with 1,000 mg of carbonate per dose will be the best at this, while Equate, and Gaviscon with 220 mg of carbonate per dose, and Gelucil with 0 mg of carbonate per dose, will be the worst at neutralizing acid. (Table 1) Table 1.) Carbonate content per dose of each antacid tested Brand Carbonate per dose (mg) Publix Regular Strength 1,000 Walgreens Regular Strength 1,000 Tums Ultra 2,000 Gelusil 0 Equate Extra Strength 220 Gaviscon Extra Strength 220 Mylanta 1000 Procedures: 1. I cleaned the mortar and pestle as well as the beaker 2. I crushed 1 dose of our table’s assigned antacid, and then dissolved it into 50 mL of 0.155 molar HCl in a mortar and pestle until it was a slurry mixture. 3. I put the mixture in the front of our table for other groups to have easier access. 4. I then obtained a spot plate and cleaned it before using it. 5. I added 15 drops of each solution of the antacid and the HCl, making sure to have drops of about the same size. 6. We added 2 drops of the 2% phenolphthalein indicator to each acid solution
7. Then, I added a drop of NaOH and mixed well, repeating this until I had added 15 drops of NaOH into the HCl solution 8. I recorded the number of drops that were used to neutralize all the HCl 9. In a similar process, I repeated steps 5-8, using the antacid solution in place of the HCl 10. I calculated the number of moles of HCl used to neutralize per dose, by multiplying the percentage of acid neutralized by the number of moles of acid, then expressing them in scientific notation. 11. I used the number of moles of acid neutralized per dose and the mass of one mole (36.46), then calculated the number of grams of acid neutralized per dose. 12. I divided the cost per dose by the number of moles neutralized to find the cost- effectiveness of each brand per mole. 13. I divided the cost per dose by the number of neutralized grams to find each brand's cost- effectiveness per gram. Results: Table 2.) Percentage of Acid Neutralized by Each Brand Tested Compared to Active Brand Percentage of acid neutralized Carbonate per dose Hydroxide per dose Gelusil 93.33% 0 800 Mylanta 86.67% 1000 270 Publix Regular Strength 73.33% 1,000 0 Walgreens Regular Strength 73.33% 1,000 0 Tums Ultra 66.67% 2,000 0 Equate Extra Strength 60.00% 220 320 Gaviscon Extra Strength 53.33% 220 320
Graph 1.) Relative Acid Neutralizing Ability of Each Antacid with Active Ingredient 0.00% 10.00% 20.00% 30.00% 40.00% 50.00% 60.00% 70.00% 80.00% 90.00% 100.00% Publix Regular Strength Walgreens Regular Strength Tums Ultra Gelusil Equate Extra Strength Gaviscon Extra Strength Mylanta Percentage of Acid Neutralized Brand of Antacid Relative Acid Neutralizing Ability of Each Antacid With Active Ingredient Red - Active ingredient of carbonate Green - Active ingredient of hydroxide
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We had a hard time telling if some of the acids were completely neutralized, mainly with Publix Regular Strength, and Equate Extra Strength. This is because the 2% phenolphthalein indicator would become clear, but as we went further into the experiment it would go back to pink, and we would need to add more drops of NaOH. Discussion: My hypothesis was partially supported by the experiment that we ran. My prediction that carbonate as an active ingredient would be the most effective in neutralizing acid could not be supported by this experiment. Rather, the experiment supported the idea that hydroxide as an active ingredient is the most effective in neutralizing acid. As shown in Table 2, Gelucil was the most effective antacid, having eliminated 93.33% of the acid. Gelucil as an antacid had no carbonate in a dose, rather, had 800 mg of hydroxide per dose. However, the results yielded from this experiment seem to not heavily support one result over the other. While it seems as if hydroxide is the most effective in reducing acid, due to how effective Gelucil is as an antacid, an Table 2 is organized in order of most effective to least effective, and Mylanta, an antacid with high amounts of carbonate as an active ingredient, ranked second. My ranking of how effective the antacids would be was partially supported, as through this experiment, Gaviscon and Equate were shown to be the least effective. Mylanta, Publix Regular Strength, and Walgreens Regular Strength’s ranks were all supported by the experiment as well. While I did like the design of the experiment, specifically how each table had a different antacid during prep, as I found it very time efficient, there are a couple of things about the design of the lab that I would change. I would make sure that each antacid only has one active ingredient. This would help with the data giving a clearer idea of which is the most effective. A mistake that could’ve been made in the experiment is how there isn’t a clear way to get equal - sized drops using the plastic pipettes. I propose that we should begin using reusable micropipettes, as those allow for more reassurance in drop size. Overall, I believe that while there were a few parts of the experiment that could be fixed, the experimental design isn’t too flawed to the point that data would be completely inaccurate. Sodium hydroxide was the most effective antacid in an experiment of a similar fashion (3). So the results yielded from this experiment c ouldn’t have been too inaccurate. Sources: 1. https://iffgd.org/manage-your-health/diet-and- treatments/antacids/#:~:text=Calcium%20Carbonate%20%5BCaCO3%5D%20%E2%80 %93%20Calcium,can%20completely%20neutralize%20stomach%20acid 2. https://www.nhs.uk/conditions/antacids/ 3. https://www.scholarsliterature.com/article_pdf/4/scientific_4_156_07022019062117.pdf