Discussion 10 cell cycle and DNA replication redux f23 key

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Jan 9, 2024

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Bio151 Fall 2023 Discussion 10 Rounds Discussion 10 Cell Cycle and cancer Team Portion Names: TA: Discussion day/time: Using the model of the SAC below, identify the following as proto-oncogene or tumor suppressor. (0.5 each point each) 1. APC/C proto-oncogene 2. Securin tumor suppressor 3. Draw a replication fork. Include helicase, DNA polymerase, okazaki fragments. Be sure to indicate leading and lagging strand and the 5’ and 3’ end of all DNA fragments. Just use lines represent nucleic acids (not letters) (2 points) 1
Bio151 Fall 2023 Discussion 10 Rounds 4. One mitotic chromosome is shown, draw in a homologous mitotic chromosome, then label the following: kinetochore, sister chromatids, homologous chromosomes. (2 points – 0.4 for each component) What conditions are true at the given points (a=true, b=false) (0.5 points each) 6. At point 3, APC/C should be bound to CDC20 A 7. At point 2, Wee1 should be phosphorylated A 2
Bio151 Fall 2023 Discussion 10 Rounds Discussion 10 Cell Cycle and DNA Replication Individual Portion Name: TA: Discussion day/time: For the following select: (0.5 points each) A: oncogene B: proto-oncogene C: tumor suppressor D: none of the above 1. Unmutated Rb1 in a cell (non-cancerous cell). C 2. Gain of function mutation on E2F in a cell A 3. One of the ends of the DNA at right is labeled 5’. Label the other three ends, then add in the direction of polymerase movement for each strand. 1 point 4. Label leading and lagging strand 1 point 3
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Bio151 Fall 2023 Discussion 10 Rounds 5. chromosomes are different before and after S phase. What is the difference? What is the difference? If you wish you can draw it. (1 points) the chromosome has been replicated and consist of two chromatids 4

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