1)How do genetic mutations arise

Names: ~otalaiy B o V¢ rapjfoNn 1)How do genetic mutations arise? A chano i i y | v VI { { ¥ 2) Are changes to a DNA sequence good? Bad? Neutral? Why? (AU A004 .} 1 ¥ ranay fyoim (NAtr ne) YRpreffion 0F e 0y P Tty o A pronda 3) The section of DNA shown below is the gene for a very small protein. Determine the sequence of the mRNA, labeling the 5’ and 3’ ends. Use the amino acid chart to determine the sequence of this protein Template LY > Non-Template strand G 37 mRNA ( ":‘f\'\’kk( ‘\‘ 1A \AAG \C G H ; ? protein MET THR-VAL-LEY A DNA mutation occurred, resulting in the insertion of a single base shown in bold. How has the protein changed? Template - o 5! Non-Template strand 5* ¥ mRNA 5C U ANAGH A ( ‘“L‘fj"“lv-\ CUINUA AGCUG protein M (A ““'v /\ \ [ i ‘l”\,/ | y ‘*’ v How has the protein changed? Is this change likely to disrupt the function of the protein? o more op Codon - Mon fense mut 7inon

4) The mRNA shown below codes for a very small protein. Determine the sequence of the non-template DNA, labeling the 5’ and 3’ ends Determine the sequence of the template DNA, labeling the 5’ and 3’ ends Use the amino acid chart to determine the amino acids in this protein mRNA cARUGeABCGRUALA Template CTTACONT B4 oy 2} CY @ G Non-template strand CANTE (‘t 2 ol \Hr \4‘(|ij "( C 'i‘r;};u':rz GCEATAC (e 6T A Protein Metr La Maltlke Pro There was a single base change in the DNA sequence resulting in the following mRNA. How has the protein changed? mRNA CARUGCUAGCURUAL \}H{ Ap 3 Protein Mgt Lutt A\a |1 HiS AvY How has the protein changed? Is this change likely to disrupt the function of the protein? e o difherent Yr‘fih(,wu Second letter u © A G vuu ucu UAU . uGu u oue JPt | uce - act™r (lgeJor | ¢ Ylouay,q, [UCA UAA Stop UGA Stop| A uuo} | uce UAG Stop UGG Trp |G cuu) | ccu CAUY 4 |CSY) u cuc ccc cac™ fcec|, . |C 5 1€ cua [** ] cca [P lcmy g, caa (A9 | A 5 gl lcue cce CAG €6 G| § < ° B AUU ACU AAU}M, A(_,«f}ge( u £ @ A AUC tlle | ACC o AAC J AGC ClE AUA f ACA AAA }1v<. AGA }A,g A Met | ACG AAG AGG G GuU Gcu GAU pgp | OGU u @ C"'Clvas GCC | \a mc} P |gGe oy |S GUA GCA GAA} G, |GGA A GUG J GCG GAG GGG [