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Chapter A, Problem 4P

A man, J.B., has a sister with autosomal recessive galactosemia (OMIM 230400 ), and his partner, S.B., has a brother with galactosemia. Galactosemia is a serious condition caused by an enzyme deficiency that prevents the metabolism of the sugar galactose. Neither J.B. nor S.B. has galactosemia, but they are concerned about the risk that a future child of theirs will have the condition. What is the probability their first child will have galactosemia?

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AaBbCc X AaBbCc individuals are crossed. What is the probability of their offspring having a genotype AABBCC?
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