Organic Chemistry As a Second Language: Second Semester Topics
Organic Chemistry As a Second Language: Second Semester Topics
4th Edition
ISBN: 9781119110651
Author: David R. Klein
Publisher: WILEY
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Chapter 9.4, Problem 9.25P
Interpretation Introduction

Interpretation:

Efficient synthesis for the given transformation has to be proposed.

Organic Chemistry As a Second Language: Second Semester Topics, Chapter 9.4, Problem 9.25P

Concept Introduction:

Amino group is a very active group.  It is a strong activator when present on the aromatic ring.  In order to reduce the activation, the amino group is acylated using any acid chloride.  Acylated amino group is a moderate activator.  When the amino group is acylated, the para position undergoes reaction without any other side reactions.  Once when the required group is installed in the para position, the acyl group is removed from the amine by treatment with acid.

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Organic Chemistry As a Second Language: Second Semester Topics

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