Chapter 9, Problem 8TYU

Summary Introduction

To analyze: The allosteric regulation of the enzyme phosphofructokinase by ATP and related molecules during glycolysis and to find whether the ATP that is considered to be allosteric regulator inhibits or stimulates the activity of the enzyme phosphofructokinase.

Concept introduction:

The enzyme phosphofructokinase plays its role in the most important regulatory step (energy investment step) of glycolysis. It converts fructose-6 phosphate to fructose-1,6 bisphosphate. The regulation of phosphofructokinase is said to be allosteric due to the binding of an effector molecule other than the enzyme's active site. Adenosine triphosphate (ATP) is known as the allosteric regulator for this enzyme in this step of glycolysis.