Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
2nd Edition
ISBN: 9780134754239
Author: Erin C. Amerman
Publisher: PEARSON
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Textbook Question
Chapter 9, Problem 5CYR
Which function is being fulfilled by a muscle that holds a bone steady during movement?
a. Antagonist
b. Synergist
c. Supinator
d. Fixator
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 9 Solutions
Human Anatomy & Physiology, Books a la Carte Edition (2nd Edition)
Ch. 9.1 - What is a fascicle, and how does it relate to the...Ch. 9.1 - 2. How do the terms pennate, parallel, and...Ch. 9.1 - The adductor magnus muscle is a muscle in the...Ch. 9.1 - 4. What is the role of an agonist in a muscle...Ch. 9.1 - What are a muscles origin and insertion, and how...Ch. 9.1 - 6. How do first-, second-, and third-class lever...Ch. 9.2 - 1. How do the muscles of facial expression differ...Ch. 9.2 - Which muscles are involved in opening and closing...Ch. 9.2 - What are three muscles involved in producing happy...Ch. 9.2 - Which muscles are involved in producing frowning...
Ch. 9.2 - Which extrinsic eye muscles pull the eyeball...Ch. 9.2 - Prob. 6QCCh. 9.2 - Prob. 7QCCh. 9.2 - Prob. 8QCCh. 9.2 - Prob. 9QCCh. 9.2 - What are the three main muscles of the erector...Ch. 9.2 - 11. What additional roles besides supporting...Ch. 9.3 - What is the main muscle of inspiration, and where...Ch. 9.3 - What roles do the external and internal...Ch. 9.3 - Which muscles are involved in trunk flexion?Ch. 9.3 - Prob. 4QCCh. 9.3 - Prob. 5QCCh. 9.3 - Prob. 6QCCh. 9.4 - Prob. 1QCCh. 9.4 - Which posterior trunk muscles act on the scapula?...Ch. 9.4 - Prob. 3QCCh. 9.4 - 4. What are two muscles that adduct the arm?
Ch. 9.4 - Prob. 5QCCh. 9.4 - Prob. 6QCCh. 9.5 - Prob. 1QCCh. 9.5 - Prob. 2QCCh. 9.5 - Prob. 3QCCh. 9.5 - Prob. 4QCCh. 9 - Which type of muscle fascicle pattern has an...Ch. 9 - 2. If “adductor” is part of the name of a muscle,...Ch. 9 - Match the term with its description: _____Brevis...Ch. 9 - Prob. 4CYRCh. 9 - 5. Which function is being fulfilled by a muscle...Ch. 9 - Prob. 6CYRCh. 9 - Which eye muscle passes through the trochlea and...Ch. 9 - Prob. 8CYRCh. 9 - Prob. 9CYRCh. 9 - Prob. 10CYRCh. 9 - 11. Match the muscle with its main...Ch. 9 - Prob. 12CYRCh. 9 - Prob. 13CYRCh. 9 - Prob. 14CYRCh. 9 - Prob. 15CYRCh. 9 - Prob. 16CYRCh. 9 - Prob. 1CYUCh. 9 - Prob. 2CYUCh. 9 - Prob. 3CYUCh. 9 - Prob. 4CYUCh. 9 - Prob. 5CYUCh. 9 - The rectus femoris muscle originates from the...Ch. 9 - Prob. 1AYKACh. 9 - Prob. 2AYKACh. 9 - Prob. 3AYKACh. 9 - Prob. 4AYKACh. 9 - Prob. 5AYKB
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