Chapter 9, Problem 3P

The calculations of the average restriction fragment size in Fig. 9.2 assume that DNA is composed equally of the four possible nucleotides. However, many genomes are somewhat enriched for certain nucleotides relative to others. As an example, the human genome is 29.6% A, 29.6% T, 20.4% C and 20.4% G. With this more accurate information in hand, re-estimate the average sizes of the pieces created by cleaving the human genome with enzymes (a–i) in the preceding Problem 9.2.