Chapter 9, Problem 2DAA

Summary Introduction

To determine: The concentration of RIP at which all of different kinds of cancer cells survive.

Introduction: Ribosome-inactivating proteins (RIPs) inactivate the ribosomes and prevent protein synthesis in a cell. It removes adenine base from ribosomal rRNA that forms the part of binding site for proteins involved in GTP. This results in inability of ribosome to bind to these proteins and protein synthesis stops. The toxic RIPs have a domain that makes them enter into another that interferes with ribosome. They have antiviral and anticancer properties, and are used to design drugs for HIV and cancer.