CONNECT WITH LEARNSMART FOR COWAN: MICR
3rd Edition
ISBN: 2818440123740
Author: Cowan
Publisher: MCG
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Textbook Question
Chapter 9, Problem 19Q
The most versatile method for sterilizing heat-sensitive liquids is
- a. UV radiation.
- b. exposure to ozone.
- c. peracetic acid.
- d. filtration.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 9 Solutions
CONNECT WITH LEARNSMART FOR COWAN: MICR
Ch. 9.1 - Clearly define the terms sterilization,...Ch. 9.1 - Prob. 2AYPCh. 9.1 - Compare the action of microbicidal and...Ch. 9.1 - Name four categories of cellular targets for...Ch. 9.2 - Prob. 5AYPCh. 9.2 - Prob. 6AYPCh. 9.2 - Prob. 7AYPCh. 9.2 - Prob. 8AYPCh. 9.2 - Prob. 9AYPCh. 9.2 - Prob. 10AYP
Ch. 9.2 - Differentiate between the two types of radiation...Ch. 9.2 - Prob. 12AYPCh. 9.3 - Name the desirable characteristics of chemical...Ch. 9.3 - Prob. 14AYPCh. 9.3 - List advantages and disadvantages to phenolic...Ch. 9.3 - Prob. 16AYPCh. 9.3 - Prob. 17AYPCh. 9.3 - Identify some heavy metal control agents.Ch. 9.3 - Prob. 19AYPCh. 9.3 - Identify applications for ethylene oxide...Ch. 9.3 - Prob. 1MMCh. 9.3 - Prob. 2NPCh. 9.3 - Q. What is the mode of action of chlorhexidine?Ch. 9.3 - In the health care environment, use of...Ch. 9 - Prob. 1NPCh. 9 - Prob. 1QCh. 9 - Prob. 2QCh. 9 - Triclosan and other antimicrobial compounds have...Ch. 9 - Microbial control methods that kill _____ are able...Ch. 9 - Prob. 5QCh. 9 - Prob. 6QCh. 9 - Prob. 7QCh. 9 - Prob. 8QCh. 9 - Prob. 9QCh. 9 - Prob. 10QCh. 9 - Do you think UV radiation is a good way to...Ch. 9 - Suggest a possible mechanism for how a microbe...Ch. 9 - Prob. 13QCh. 9 - Prob. 14QCh. 9 - What additional considerations would you have to...Ch. 9 - Sanitization is a process by which a. the...Ch. 9 - Prob. 17QCh. 9 - Defend this statement: It is possible to make our...Ch. 9 - The most versatile method for sterilizing...Ch. 9 - Precisely what is microbial death?Ch. 9 - Prob. 21QCh. 9 - From chapter 3, figure 3.15. Study this...
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