Campbell Biology (10th Edition)
Campbell Biology (10th Edition)
10th Edition
ISBN: 9780321775658
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
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Chapter 9, Problem 10TYU

INTERPRET THE DATA Phosphofructokinase is an enzyme that acts on fructose 6-phosphate at an early step in glucose breakdown. Regulation of this enzyme controls whether the sugar will continue on in the glycolytic pathway. Considering this graph, under which condition is phosphofructokinase more active? Given what you know about glycolysis and regulation of metabolism by this enzyme, explain the mechanism by which phosphofructokinase activity differs depending on ATP concentration. Explain why it makes sense that regulation of this enzyme has evolved so that it works this way.

Chapter 9, Problem 10TYU, INTERPRET THE DATA Phosphofructokinase is an enzyme that acts on fructose 6-phosphate at an early

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Consider ten glucose molecules that enter a cell. How many ATP can be generated by the complete catabolism of these into CO2 and H2O? If all ten are first incorporated into glycogen, liberated from glycogen, and then fully catabolized into CO2 and H2O, does the ATP tally increase, decrease or stay the same? Consider that 1 UTP = 1 ATP. Explain. Describe the processes which produce ATP and provide a balanced equation of glucose, CO2, H2O and O2
Design a radiotracer experiment that would allow you to determine which proportion of glucose catabolism in a given tissue prepara- tion occurs through the pentose phosphate pathway and which pro- portion through glycolysis and the citric acid cycle. Assume that you can synthesize glucose labeled with 1"C in any desired position or combination of positions. Assume also that you can trap CO, after administration of labeled glucose and determine its radioactivity.

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Campbell Biology (10th Edition)

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