HUMAN ANATOMY
6th Edition
ISBN: 9781260210262
Author: SALADIN
Publisher: RENT MCG
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Chapter 8, Problem 7WWWTS
Summary Introduction
To explain:
The reason humerus is not the most frequently broken bone and which one is most frequently broken bone.
Introduction:
The humerus forms the brachium of the forearm that is present between the shoulder and elbow.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 8 Solutions
HUMAN ANATOMY
Ch. 8.1 - Prob. 1AWYKCh. 8.1 - Describe how to distinguish the medical and...Ch. 8.1 - Prob. 2BYGOCh. 8.1 - Prob. 3BYGOCh. 8.1 - Name the carpal bones of the proximal row from...Ch. 8.1 - Name the four long bones from the tip of the...Ch. 8.1 - Palpate as many of the following structures as...Ch. 8.2 - Prob. 1AWYKCh. 8.2 - Prob. 7BYGOCh. 8.2 - Prob. 8BYGO
Ch. 8.2 - Prob. 9BYGOCh. 8.2 - Prob. 10BYGOCh. 8.2 - Name the prominent knobs on each side of your...Ch. 8.2 - Prob. 12BYGOCh. 8.2 - Prob. 13BYGOCh. 8.3 - Prob. 14BYGOCh. 8.3 - Prob. 15BYGOCh. 8.3 - Prob. 16BYGOCh. 8 - The function of the pectoral girdle; the bones...Ch. 8 - Prob. 8.1.2AYLOCh. 8 - The four segments (regions) of the upper limbCh. 8 - The names and locations of all 30 bones of the...Ch. 8 - The anatomical features of the humerus, radius,...Ch. 8 - How the upper limb is anatomically adapted to the...Ch. 8 - Prob. 8.2.1AYLOCh. 8 - The function of the pelvic girdle; the bones that...Ch. 8 - Prob. 8.2.3AYLOCh. 8 - Prob. 8.2.4AYLOCh. 8 - Prob. 8.2.5AYLOCh. 8 - Prob. 8.2.6AYLOCh. 8 - Prob. 8.2.7AYLOCh. 8 - Prob. 8.2.8AYLOCh. 8 - The anatomical features of the femur, patella,...Ch. 8 - Prob. 8.2.10AYLOCh. 8 - How the lower limb is adapted to the bipedalism of...Ch. 8 - What portions of the appendicular skeleton are...Ch. 8 - Prob. 8.3.2AYLOCh. 8 - Prob. 8.3.3AYLOCh. 8 - Prob. 8.3.4AYLOCh. 8 - Prob. 8.3.5AYLOCh. 8 - Prob. 1TYRCh. 8 - Prob. 2TYRCh. 8 - Prob. 3TYRCh. 8 - Prob. 4TYRCh. 8 - Prob. 5TYRCh. 8 - When you rest your hands on your hips, you are...Ch. 8 - Prob. 7TYRCh. 8 - Prob. 8TYRCh. 8 - Prob. 9TYRCh. 8 - Prob. 10TYRCh. 8 - Prob. 11TYRCh. 8 - Prob. 12TYRCh. 8 - Prob. 13TYRCh. 8 - Prob. 14TYRCh. 8 - Prob. 15TYRCh. 8 - Prob. 16TYRCh. 8 - Prob. 17TYRCh. 8 - Prob. 18TYRCh. 8 - Prob. 19TYRCh. 8 - Prob. 20TYRCh. 8 - Prob. 1BYMVCh. 8 - Prob. 2BYMVCh. 8 - Prob. 3BYMVCh. 8 - Prob. 4BYMVCh. 8 - State a meaning of each word element and give a...Ch. 8 - Prob. 6BYMVCh. 8 - Prob. 7BYMVCh. 8 - Prob. 8BYMVCh. 8 - Prob. 9BYMVCh. 8 - Prob. 10BYMVCh. 8 - Prob. 1WWWTSCh. 8 - Prob. 2WWWTSCh. 8 - Prob. 3WWWTSCh. 8 - Prob. 4WWWTSCh. 8 - Prob. 5WWWTSCh. 8 - Prob. 6WWWTSCh. 8 - Prob. 7WWWTSCh. 8 - Prob. 8WWWTSCh. 8 - Prob. 9WWWTSCh. 8 - Briefly explaine why each of the following...Ch. 8 - Prob. 1TYCCh. 8 - Prob. 2TYCCh. 8 - A deer hunter discovers a human skeleton in the...Ch. 8 - Prob. 4TYCCh. 8 - Andy, a 55-year-old, 75 kg (165-pound) roofer, is...
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