BIOCHEMISTRY BOOKS ALC&MOD MST/ET PKG
1st Edition
ISBN: 9780134172507
Author: APPLING
Publisher: Pearson Education
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Chapter 8, Problem 3P
An enzyme contains an active site aspartic acid with a pKa = 5.0, which acts as a general acid catalyst. On the accompanying template, draw the curve of enzyme activity (reaction rate) versus pH for the enzyme (assume that the protein is stably folded between pH 2-12 and that the active site Asp is the only ionizable residue involved in catalysis). Briefly explain the shape of your curve.
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7. Which one is the major organic product obtained from the following reaction?
CHO
COOH
CH₂OH
CHO
COOH
H-
-OH
H₂
H-
OH
H-
-OH
H-
-OH
Ni
HO
-H
HO
-H
HO-
-H
HO-
H
HO-
H
H-
-OH
H-
-OH
H-
-OH
H
-OH
H-
-OH
H-
-OH
H-
-OH
H-
-OH
H-
-OH
H
-OH
CH₂OH
CH₂OH
CH₂OH
CH₂OH
COOH
A
B
C
D
4. The compound on the right is-
B) a ketopentose C) an aldohexose
A) an aldopentose
D) a ketohexose
E) a ketoheptose
OH OH
CH2OH
OH
12. When glutamic acid is heated to 180°C., it loses a molecule of water to form a
lactam. The bond that creates the lactam is an amide bond that forms between the
amino nitrogen and the carbon of the side chain -COOH group. What is the most
reasonable structure for this lactam? (NOTE: The structure of glutamic acid is shown
in Question 1.)
COOH
COOH
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C
D
COOH
B
COOH
E
COOH
Chapter 8 Solutions
BIOCHEMISTRY BOOKS ALC&MOD MST/ET PKG
Ch. 8 - Prob. 1PCh. 8 - The enzyme urease catalyzes the hydrolysis of urea...Ch. 8 - An enzyme contains an active site aspartic acid...Ch. 8 - The folding and unfolding rate constants for a...Ch. 8 - In some reactions, in which a protein molecule is...Ch. 8 - Would you expect an “enzyme” designed to bind to...Ch. 8 - The initial rate for an enzyme-catalyzed reaction...Ch. 8 - a. If the total enzyme concentration in Problem 7...Ch. 8 - Prob. 9PCh. 8 - Prob. 10P
Ch. 8 - The following data describe the catalysis of...Ch. 8 - At 37 oC, the serine protease subtilisin has kcat...Ch. 8 - The accompanying figure shows three...Ch. 8 - The steady-state kinetics of an enzyme are studied...Ch. 8 - The same enzyme as in Problem 14 is studied in the...Ch. 8 - Enalapril is an anti-hypertension “pro-drug"...Ch. 8 - Initial rate data for an enzyme that obeys...Ch. 8 - Prob. 18PCh. 8 - Suggest the effects of each of the following...Ch. 8 - The inhibitory effect of an uncompetitive...Ch. 8 - Prob. 21P
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