ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
3rd Edition
ISBN: 9781264013470
Author: McKinley
Publisher: MCGRAW-HILL LEARNING SOLN.(CC)
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Chapter 8, Problem 17DYB
What are the primary similarities and differences between the upper and lower limbs?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 8 Solutions
ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
Ch. 8.1 - LEARNING OBJECTIVE
1. Compare and contrast the...Ch. 8.1 - What is the general function of the axial...Ch. 8.1 - Prob. 2LOCh. 8.1 - What is the difference between a foramen and a...Ch. 8.2 - LEARNING OBJECTIVE
3. Distinguish between the...Ch. 8.2 - Prob. 3WDLCh. 8.2 - Prob. 4LOCh. 8.2 - Prob. 5LOCh. 8.2 - Prob. 6LOCh. 8.2 - Prob. 1WDT
Ch. 8.2 - Prob. 4WDLCh. 8.2 - What bones form the middle cranial fossa, and...Ch. 8.2 - Prob. 7LOCh. 8.2 - Prob. 6WDLCh. 8.2 - Prob. 8LOCh. 8.2 - Prob. 9LOCh. 8.2 - Prob. 7WDLCh. 8.2 - In which four bones are the paranasal sinuses...Ch. 8.3 - Prob. 10LOCh. 8.3 - Prob. 11LOCh. 8.3 - Prob. 9WDLCh. 8.4 - Prob. 12LOCh. 8.4 - Prob. 2WDTCh. 8.4 - What are some features that differ between female...Ch. 8.4 - Prob. 13LOCh. 8.4 - Prob. 14LOCh. 8.4 - What are the two largest fontanelles, and when do...Ch. 8.5 - Prob. 15LOCh. 8.5 - Prob. 16LOCh. 8.5 - Prob. 12WDLCh. 8.5 - Prob. 17LOCh. 8.5 - LEARNING OBJECTIVES
18. Explain the sequence of...Ch. 8.5 - What are the secondary curves, and when do they...Ch. 8.5 - Prob. 19LOCh. 8.5 - Prob. 20LOCh. 8.5 - Prob. 3WDTCh. 8.5 - Compare the locations and functions of the...Ch. 8.5 - Prob. 15WDLCh. 8.6 - Prob. 21LOCh. 8.6 - Prob. 16WDLCh. 8.6 - Prob. 22LOCh. 8.6 - Prob. 23LOCh. 8.6 - Where specifically do the head and tubercle of a...Ch. 8.7 - Prob. 24LOCh. 8.7 - Prob. 25LOCh. 8.7 - Prob. 18WDLCh. 8.8 - Prob. 26LOCh. 8.8 - How do the sternal end and acromial end of the...Ch. 8.8 - Prob. 27LOCh. 8.8 - Prob. 20WDLCh. 8.9 - Prob. 28LOCh. 8.9 - Prob. 29LOCh. 8.9 - Prob. 21WDLCh. 8.9 - Prob. 22WDLCh. 8.9 - Prob. 30LOCh. 8.9 - Prob. 31LOCh. 8.9 - Prob. 32LOCh. 8.9 - Prob. 23WDLCh. 8.9 - Describe how the radius and ulna are positioned...Ch. 8.9 - Prob. 33LOCh. 8.9 - Prob. 34LOCh. 8.9 - List the eight carpal bones. Which of these bones...Ch. 8.10 - Prob. 35LOCh. 8.10 - LEARNING OBJECTIVES
36. Describe how the ossa...Ch. 8.10 - Prob. 37LOCh. 8.10 - WHAT DO YOU THINK?
4 Compare and contrast the...Ch. 8.10 - What three bones fuse to form the os coxae?Ch. 8.10 - Prob. 27WDLCh. 8.10 - Prob. 38LOCh. 8.10 - Prob. 39LOCh. 8.10 - How is the pelvic inlet distinguished from the...Ch. 8.10 - Prob. 40LOCh. 8.10 - Prob. 29WDLCh. 8.10 - Prob. 41LOCh. 8.10 - What are some differences in the symphysial...Ch. 8.11 - Prob. 42LOCh. 8.11 - Prob. 43LOCh. 8.11 - Prob. 44LOCh. 8.11 - Prob. 31WDLCh. 8.11 - Prob. 32WDLCh. 8.11 - Prob. 45LOCh. 8.11 - Prob. 46LOCh. 8.11 - Prob. 47LOCh. 8.11 - WHAT DO YOU THINK?
5 The medial and lateral...Ch. 8.11 - What are some bony features that are similar or...Ch. 8.11 - Prob. 34WDLCh. 8.11 - LEARNING OBJECTIVES
48. Locate and identify the...Ch. 8.11 - Prob. 49LOCh. 8.11 - Prob. 35WDLCh. 8.11 - Prob. 50LOCh. 8.11 - Prob. 36WDLCh. 8.12 - Prob. 51LOCh. 8.12 - Prob. 52LOCh. 8.12 - Prob. 37WDLCh. 8 - Prob. 1DYBCh. 8 - Which bone marking is matched with its correct...Ch. 8 - The frontal and parietal bones articulate at the...Ch. 8 - Prob. 4DYBCh. 8 - Prob. 5DYBCh. 8 - Prob. 6DYBCh. 8 - Prob. 7DYBCh. 8 - Prob. 8DYBCh. 8 - The femur articulates with the tibia at the a....Ch. 8 - Prob. 10DYBCh. 8 - Prob. 11DYBCh. 8 - Prob. 12DYBCh. 8 - What are the functions of the paranasal sinuses?Ch. 8 - Prob. 14DYBCh. 8 - Describe similarities and differences among true,...Ch. 8 - Compare and contrast the anatomic and functional...Ch. 8 - What are the primary similarities and differences...Ch. 8 - Prob. 18DYBCh. 8 - Prob. 19DYBCh. 8 - Prob. 20DYBCh. 8 - Prob. 1CALCh. 8 - Prob. 2CALCh. 8 - Prob. 3CALCh. 8 - Prob. 4CALCh. 8 - Use the following paragraph to answer questions...Ch. 8 - Prob. 1CSLCh. 8 - Prob. 2CSLCh. 8 - Forensic anthropologists are investigating...
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